Search Results
Overview
| Uniprot ID | Q9UIJ7 |
|---|---|
| Protein Name | GTP:AMP phosphotransferase AK3, mitochondrial |
| Gene Name | AK3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 171 | DKPETVIKRLKAYED |
| 174 | ETVIKRLKAYEDQTK |
| 189 | PVLEYYQKKGVLETF |
| 20 | MGAPGSGKGTVSSRI |
| 34 | ITTHFELKHLSSGDL |
| 64 | KAFIDQGKLIPDDVM |
Function
Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity (PubMed:11485571, PubMed:32822537). Could also use ITP as phosphate donor (PubMed:11485571). Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix (Probable)
Protein Sequence
10
MGASARLLRA
20
VIMGAPGSGK
30
GTVSSRITTH
40
FELKHLSSGD
50
LLRDNMLRGT
60
EIGVLAKAFI
70
DQGKLIPDDV
80
MTRLALHELK
90
NLTQYSWLLD
100
GFPRTLPQAE
110
ALDRAYQIDT
120
VINLNVPFEV
130
IKQRLTARWI
140
HPASGRVYNI
150
EFNPPKTVGI
160
DDLTGEPLIQ
170
REDDKPETVI
180
KRLKAYEDQT
190
KPVLEYYQKK
200
GVLETFSGTE
210
TNKIWPYVYA
220
FLQTKVPQRS
QKASVTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016874 | ligase activity |
| Molecular Function | GO:0046899 | nucleoside triphosphate adenylate kinase activity |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0046039 | GTP metabolic process |
| Biological Process | GO:0046041 | ITP metabolic process |
| Biological Process | GO:0009142 | nucleoside triphosphate biosynthetic process |
| Biological Process | GO:0046051 | UTP metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.