Search Results
Overview
| Uniprot ID | Q9UJ41 |
|---|---|
| Protein Name | Rab5 GDP/GTP exchange factor |
| Gene Name | RABGEF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 213 | KIMDQIEKYIMTRLY |
Function
Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:15339665, PubMed:9323142). Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:11452015, PubMed:9323142). Also functions as a ubiquitin ligase (By similarity)
Protein Sequence
10
MSLKSERRGI
20
HVDQSDLLCK
30
KGCGYYGNPA
40
WQGFCSKCWR
50
EEYHKARQKQ
60
IQEDWELAER
70
LQREEEEAFA
80
SSQSSQGAQS
90
LTFSKFEEKK
100
TNEKTRKVTT
110
VKKFFSASSR
120
VGSKKEIQEA
130
KAPSPSINRQ
140
TSIETDRVSK
150
EFIEFLKTFH
160
KTGQEIYKQT
170
KLFLEGMHYK
180
RDLSIEEQSE
190
CAQDFYHNVA
200
ERMQTRGKVP
210
PERVEKIMDQ
220
IEKYIMTRLY
230
KYVFCPETTD
240
DEKKDLAIQK
250
RIRALRWVTP
260
QMLCVPVNED
270
IPEVSDMVVK
280
AITDIIEMDS
290
KRVPRDKLAC
300
ITKCSKHIFN
310
AIKITKNEPA
320
SADDFLPTLI
330
YIVLKGNPPR
340
LQSNIQYITR
350
FCNPSRLMTG
360
EDGYYFTNLC
370
CAVAFIEKLD
380
AQSLNLSQED
390
FDRYMSGQTS
400
PRKQEAESWS
410
PDACLGVKQM
420
YKNLDLLSQL
430
NERQERIMNE
440
AKKLEKDLID
450
WTDGIAREVQ
460
DIVEKYPLEI
470
KPPNQPLAAI
480
DSENVENDKL
490
PPPLQPQVYA
G
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0098830 | presynaptic endosome |
| Cellular Component | GO:0055037 | recycling endosome |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0098935 | dendritic transport |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:0006612 | protein targeting to membrane |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.