Search Results

Overview

Uniprot ID	Q9UJ68
Protein Name	Mitochondrial peptide methionine sulfoxide reductase
Gene Name	MSRA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
41	QEALPGRKEQTPVAA

Function

Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (PubMed:10452521, PubMed:12039877). Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency (By similarity)

Protein Sequence

10 MLSATRRACQ 20 LLLLHSLFPV 30 PRMGNSASNI 40 VSPQEALPGR 50 KEQTPVAAKH 60 HVNGNRTVEP 70 FPEGTQMAVF 80 GMGCFWGAER 90 KFWVLKGVYS 100 TQVGFAGGYT 110 SNPTYKEVCS 120 EKTGHAEVVR 130 VVYQPEHMSF 140 EELLKVFWEN 150 HDPTQGMRQG 160 NDHGTQYRSA 170 IYPTSAKQME 180 AALSSKENYQ 190 KVLSEHGFGP 200 ITTDIREGQT 210 FYYAEDYHQQ 220 YLSKNPNGYC 230 GLGGTGVSCP VGIKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0033744	L-methionine (S)-S-oxide reductase activity
Molecular Function	GO:0008113	peptide-methionine (S)-S-oxide reductase activity
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0006555	methionine metabolic process
Biological Process	GO:0036211	protein modification process
Biological Process	GO:0030091	protein repair
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.