Overview
| Uniprot ID | Q9UJ70 |
|---|
| Protein Name | N-acetyl-D-glucosamine kinase |
|---|
| Gene Name | NAGK |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 59 |
MVNRAKRKAGVDPLV |
Function
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575)
Protein Sequence
10
MAAIYGGVEG
20
GGTRSEVLLV
30
SEDGKILAEA
40
DGLSTNHWLI
50
GTDKCVERIN
60
EMVNRAKRKA
70
GVDPLVPLRS
80
LGLSLSGGDQ
90
EDAGRILIEE
100
LRDRFPYLSE
110
SYLITTDAAG
120
SIATATPDGG
130
VVLISGTGSN
140
CRLINPDGSE
150
SGCGGWGHMM
160
GDEGSAYWIA
170
HQAVKIVFDS
180
IDNLEAAPHD
190
IGYVKQAMFH
200
YFQVPDRLGI
210
LTHLYRDFDK
220
CRFAGFCRKI
230
AEGAQQGDPL
240
SRYIFRKAGE
250
MLGRHIVAVL
260
PEIDPVLFQG
270
KIGLPILCVG
280
SVWKSWELLK
290
EGFLLALTQG
300
REIQAQNFFS
310
SFTLMKLRHS
320
SALGGASLGA
330
RHIGHLLPMD
340
YSANAIAFYS
YTFS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0160047 |
muramyl dipeptide kinase activity |
| Molecular Function |
GO:0045127 |
N-acetylglucosamine kinase activity |
| Molecular Function |
GO:0009384 |
N-acylmannosamine kinase activity |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0006046 |
N-acetylglucosamine catabolic process |
| Biological Process |
GO:0006044 |
N-acetylglucosamine metabolic process |
| Biological Process |
GO:0006051 |
N-acetylmannosamine metabolic process |
| Biological Process |
GO:0019262 |
N-acetylneuraminate catabolic process |
| Biological Process |
GO:0070434 |
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| Biological Process |
GO:0032495 |
response to muramyl dipeptide |
| Biological Process |
GO:0006048 |
UDP-N-acetylglucosamine biosynthetic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.