Search Results
Overview
| Uniprot ID | Q9UJ83 |
|---|---|
| Protein Name | 2-hydroxyacyl-CoA lyase 1 |
| Gene Name | HACL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 234 | AHAEESIKKLVEQYK |
| 365 | KSNEAASKELASKKS |
| 540 | QTPEELQKSLRQSLA |
| 566 | IEPQATRKAQDFHWL |
Function
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity)
Protein Sequence
10
MPDSNFAERS
20
EEQVSGAKVI
30
AQALKTQDVE
40
YIFGIVGIPV
50
TEIAIAAQQL
60
GIKYIGMRNE
70
QAACYAASAI
80
GYLTSRPGVC
90
LVVSGPGLIH
100
ALGGMANANM
110
NCWPLLVIGG
120
SSERNQETMG
130
AFQEFPQVEA
140
CRLYTKFSAR
150
PSSIEAIPFV
160
IEKAVRSSIY
170
GRPGACYVDI
180
PADFVNLQVN
190
VNSIKYMERC
200
MSPPISMAET
210
SAVCTAASVI
220
RNAKQPLLII
230
GKGAAYAHAE
240
ESIKKLVEQY
250
KLPFLPTPMG
260
KGVVPDNHPY
270
CVGAARSRAL
280
QFADVIVLFG
290
ARLNWILHFG
300
LPPRYQPDVK
310
FIQVDICAEE
320
LGNNVKPAVT
330
LLGNIHAVTK
340
QLLEELDKTP
350
WQYPPESKWW
360
KTLREKMKSN
370
EAASKELASK
380
KSLPMNYYTV
390
FYHVQEQLPR
400
DCFVVSEGAN
410
TMDIGRTVLQ
420
NYLPRHRLDA
430
GTFGTMGVGL
440
GFAIAAAVVA
450
KDRSPGQWII
460
CVEGDSAFGF
470
SGMEVETICR
480
YNLPIILLVV
490
NNNGIYQGFD
500
TDTWKEMLKF
510
QDATAVVPPM
520
CLLPNSHYEQ
530
VMTAFGGKGY
540
FVQTPEELQK
550
SLRQSLADTT
560
KPSLINIMIE
570
PQATRKAQDF
HWLTRSNM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0106359 | 2-hydroxyacyl-CoA lyase activity |
| Molecular Function | GO:0106376 | 2-hydroxyphytanoyl-CoA lyase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016830 | carbon-carbon lyase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030976 | thiamine pyrophosphate binding |
| Biological Process | GO:0001561 | fatty acid alpha-oxidation |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0097089 | methyl-branched fatty acid metabolic process |
| Biological Process | GO:1903512 | phytanic acid metabolic process |
| Biological Process | GO:0006625 | protein targeting to peroxisome |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.