Search Results
Overview
| Uniprot ID | Q9UJC3 |
|---|---|
| Protein Name | Protein Hook homolog 1 |
| Gene Name | HOOK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 672 | IVSAWYNKSLAFQKL |
Function
Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity)
Protein Sequence
10
MEETQPPPQP
20
KLPLCDSLMI
30
WLQTFNTASP
40
CQDVKQLTSG
50
VAMAQVLHQI
60
DAAWFNESWL
70
SRIKEDVGDN
80
WRIKASNVKK
90
VLQGIMSYYH
100
EFLGQQISEA
110
LIPDLNQITE
120
CSDPVELGRL
130
LQLILGCAIN
140
CEKKQEHIQN
150
IMTLEESVQH
160
VVMTAIQELM
170
SKEILSSPPN
180
DAVGELEQQL
190
KRALEELQEA
200
LAEKEELRQR
210
CEELDMQVTT
220
LQDEKNSLVS
230
ENEMMNEKLD
240
QLDGSFDDPN
250
TVVAKKYFHA
260
QLQLEQLQEE
270
NFRLEAAKDD
280
YRVHCEELEK
290
QLIEFQHRND
300
ELTSLAEETR
310
ALKDEIDVLR
320
ATSDKANKLE
330
STVEIYRQKL
340
QDLNDLRKQV
350
KTLQETNMMY
360
MHNTVSLEEE
370
LKKANAARTQ
380
LETYKRQVQD
390
LHVKLSSESK
400
RADTLAFEMK
410
RLEEKHEALL
420
KEKERLIEQR
430
DTLKETNEEL
440
RCSQVQQDHL
450
NQTDASATKS
460
YENLAAEIMP
470
VEYREVFIRL
480
QHENKMLRLQ
490
QEGSENERIE
500
ELQEQLEQKH
510
RKMNELETEQ
520
RLSKERIREL
530
QQQIEDLQKS
540
LQEQGSKSEG
550
ESSSKLKQKL
560
EAHMEKLTEV
570
HEELQKKQEL
580
IEDLQPDINQ
590
NVQKINELEA
600
ALQKKDEDMK
610
AMEERYKMYL
620
EKARNVIKTL
630
DPKLNPASAE
640
IMLLRKQLAE
650
KERRIEILES
660
ECKVAKFRDY
670
EEKLIVSAWY
680
NKSLAFQKLG
690
MESRLVSGGG
700
ACSDTGACTP
710
ARSFLAQQRH
720
ITNTRRNLSV
KVPATTSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070695 | FHF complex |
| Cellular Component | GO:0005874 | microtubule |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051959 | dynein light intermediate chain binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0030705 | cytoskeleton-dependent intracellular transport |
| Biological Process | GO:0045022 | early endosome to late endosome transport |
| Biological Process | GO:0007032 | endosome organization |
| Biological Process | GO:0008333 | endosome to lysosome transport |
| Biological Process | GO:0007040 | lysosome organization |
| Biological Process | GO:1905719 | protein localization to perinuclear region of cytoplasm |
| Biological Process | GO:0098840 | protein transport along microtubule |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.