Search Results
Overview
| Uniprot ID | Q9UJK0 |
|---|---|
| Protein Name | 18S rRNA aminocarboxypropyltransferase |
| Gene Name | TSR3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 304 | RAPAEVWKGIKKRQR |
Function
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable)
Protein Sequence
10
MGRRRAARGP
20
GAEGGRPRHL
30
PTRSLEAFAE
40
EVGAALQASV
50
EPGAADGEGG
60
PGPAALPCTL
70
AMWELGHCDP
80
RRCTGRKLAR
90
LGLVRCLRLG
100
HRFGGLVLSP
110
VGKQYASPAD
120
RQLVAQSGVA
130
VIDCSWARLD
140
ETPFGKMRGS
150
HLRLLPYLVA
160
ANPVNYGRPY
170
RLSCVEAFAA
180
TFCIVGFPDL
190
AVILLRKFKW
200
GKGFLDLNRQ
210
LLDKYAACGS
220
PEEVLQAEQE
230
FLANAKESPQ
240
EEEIDPFDVD
250
SGREFGNPNR
260
PVASTRLPSD
270
TDDSDASEDP
280
GPGAERGGAS
290
SSCCEEEQTQ
300
GRGAEARAPA
310
EVWKGIKKRQ
RD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0106388 | rRNA small subunit aminocarboxypropyltransferase activity |
| Molecular Function | GO:1904047 | S-adenosyl-L-methionine binding |
| Molecular Function | GO:0016740 | transferase activity |
| Biological Process | GO:0000455 | enzyme-directed rRNA pseudouridine synthesis |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0000154 | rRNA modification |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.