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Overview

Uniprot IDQ9UJQ4
Protein NameSal-like protein 4
Gene NameSALL4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
190 LQALRGTKVAVNQRS
381 KDEAALYKHKCKYCS
422 CGHRFTTKGNLKVHF

Function

Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells

Protein Sequence

10 MSRRKQAKPQ 20 HINSEEDQGE 30 QQPQQQTPEF 40 ADAAPAAPAA 50 GELGAPVNHP 60 GNDEVASEDE 70 ATVKRLRREE 80 THVCEKCCAE 90 FFSISEFLEH 100 KKNCTKNPPV 110 LIMNDSEGPV 120 PSEDFSGAVL 130 SHQPTSPGSK 140 DCHRENGGSS 150 EDMKEKPDAE 160 SVVYLKTETA 170 LPPTPQDISY 180 LAKGKVANTN 190 VTLQALRGTK 200 VAVNQRSADA 210 LPAPVPGANS 220 IPWVLEQILC 230 LQQQQLQQIQ 240 LTEQIRIQVN 250 MWASHALHSS 260 GAGADTLKTL 270 GSHMSQQVSA 280 AVALLSQKAG 290 SQGLSLDALK 300 QAKLPHANIP 310 SATSSLSPGL 320 APFTLKPDGT 330 RVLPNVMSRL 340 PSALLPQAPG 350 SVLFQSPFST 360 VALDTSKKGK 370 GKPPNISAVD 380 VKPKDEAALY 390 KHKCKYCSKV 400 FGTDSSLQIH 410 LRSHTGERPF 420 VCSVCGHRFT 430 TKGNLKVHFH 440 RHPQVKANPQ 450 LFAEFQDKVA 460 AGNGIPYALS 470 VPDPIDEPSL 480 SLDSKPVLVT 490 TSVGLPQNLS 500 SGTNPKDLTG 510 GSLPGDLQPG 520 PSPESEGGPT 530 LPGVGPNYNS 540 PRAGGFQGSG 550 TPEPGSETLK 560 LQQLVENIDK 570 ATTDPNECLI 580 CHRVLSCQSS 590 LKMHYRTHTG 600 ERPFQCKICG 610 RAFSTKGNLK 620 THLGVHRTNT 630 SIKTQHSCPI 640 CQKKFTNAVM 650 LQQHIRMHMG 660 GQIPNTPLPE 670 NPCDFTGSEP 680 MTVGENGSTG 690 AICHDDVIES 700 IDVEEVSSQE 710 APSSSSKVPT 720 PLPSIHSASP 730 TLGFAMMASL 740 DAPGKVGPAP 750 FNLQRQGSRE 760 NGSVESDGLT 770 NDSSSLMGDQ 780 EYQSRSPDIL 790 ETTSFQALSP 800 ANSQAESIKS 810 KSPDAGSKAE 820 SSENSRTEME 830 GRSSLPSTFI 840 RAPPTYVKVE 850 VPGTFVGPST 860 LSPGMTPLLA 870 AQPRRQAKQH 880 GCTRCGKNFS 890 SASALQIHER 900 THTGEKPFVC 910 NICGRAFTTK 920 GNLKVHYMTH 930 GANNNSARRG 940 RKLAIENTMA 950 LLGTDGKRVS 960 EIFPKEILAP 970 SVNVDPVVWN 980 QYTSMLNGGL 990 AVKTNEISVI 1000 QSGGVPTLPV 1010 SLGATSVVNN 1020 ATVSKMDGSQ 1030 SGISADVEKP 1040 SATDGVPKHQ 1050 FPHFLEENKI AVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.