Search Results

Overview

Uniprot IDQ9UJU6
Protein NameDrebrin-like protein
Gene NameDBNL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 EPECIMEKVAKASGA
134 CIMEKVAKASGANYS
144 GANYSFHKESGRFQD
172 TNAVSEIKRVGKDSF
176 SEIKRVGKDSFWAKA
182 GKDSFWAKAEKEEEN
280 ISSPQPGKLRSPFLQ
288 LRSPFLQKQLTQPET

Function

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes

Protein Sequence

10 MAANLSRNGP 20 ALQEAYVRVV 30 TEKSPTDWAL 40 FTYEGNSNDI 50 RVAGTGEGGL 60 EEMVEELNSG 70 KVMYAFCRVK 80 DPNSGLPKFV 90 LINWTGEGVN 100 DVRKGACASH 110 VSTMASFLKG 120 AHVTINARAE 130 EDVEPECIME 140 KVAKASGANY 150 SFHKESGRFQ 160 DVGPQAPVGS 170 VYQKTNAVSE 180 IKRVGKDSFW 190 AKAEKEEENR 200 RLEEKRRAEE 210 AQRQLEQERR 220 ERELREAARR 230 EQRYQEQGGE 240 ASPQRTWEQQ 250 QEVVSRNRNE 260 QESAVHPREI 270 FKQKERAMST 280 TSISSPQPGK 290 LRSPFLQKQL 300 TQPETHFGRE 310 PAAAISRPRA 320 DLPAEEPAPS 330 TPPCLVQAEE 340 EAVYEEPPEQ 350 ETFYEQPPLV 360 QQQGAGSEHI 370 DHHIQGQGLS 380 GQGLCARALY 390 DYQAADDTEI 400 SFDPENLITG 410 IEVIDEGWWR 420 GYGPDGHFGM 430 FPANYVELIE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0098793 presynapse
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005769 early endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016020 membrane
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0001726 ruffle
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0098973 structural constituent of postsynaptic actin cytoskeleton
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0006897 endocytosis
Biological Process GO:0061024 membrane organization
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0071800 podosome assembly
Biological Process GO:0016601 Rac protein signal transduction
Biological Process GO:0007416 synapse assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.