Overview
| Uniprot ID | Q9UJX2 |
|---|
| Protein Name | Cell division cycle protein 23 homolog |
|---|
| Gene Name | CDC23 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 453 |
LNQLVEAKKCYWRAY |
| 454 |
NQLVEAKKCYWRAYA |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861)
Protein Sequence
10
MAASTSMVPV
20
AVTAAVAPVL
30
SINSDFSDLR
40
EIKKQLLLIA
50
GLTRERGLLH
60
SSKWSAELAF
70
SLPALPLAEL
80
QPPPPITEED
90
AQDMDAYTLA
100
KAYFDVKEYD
110
RAAHFLHGCN
120
SKKAYFLYMY
130
SRYLSGEKKK
140
DDETVDSLGP
150
LEKGQVKNEA
160
LRELRVELSK
170
KHQARELDGF
180
GLYLYGVVLR
190
KLDLVKEAID
200
VFVEATHVLP
210
LHWGAWLELC
220
NLITDKEMLK
230
FLSLPDTWMK
240
EFFLAHIYTE
250
LQLIEEALQK
260
YQNLIDVGFS
270
KSSYIVSQIA
280
VAYHNIRDID
290
KALSIFNELR
300
KQDPYRIENM
310
DTFSNLLYVR
320
SMKSELSYLA
330
HNLCEIDKYR
340
VETCCVIGNY
350
YSLRSQHEKA
360
ALYFQRALKL
370
NPRYLGAWTL
380
MGHEYMEMKN
390
TSAAIQAYRH
400
AIEVNKRDYR
410
AWYGLGQTYE
420
ILKMPFYCLY
430
YYRRAHQLRP
440
NDSRMLVALG
450
ECYEKLNQLV
460
EAKKCYWRAY
470
AVGDVEKMAL
480
VKLAKLHEQL
490
TESEQAAQCY
500
IKYIQDIYSC
510
GEIVEHLEES
520
TAFRYLAQYY
530
FKCKLWDEAS
540
TCAQKCCAFN
550
DTREEGKALL
560
RQILQLRNQG
570
ETPTTEVPAP
580
FFLPASLSAN
590
NTPTRRVSPL
NLSSVTP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005680 |
anaphase-promoting complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0140767 |
enzyme-substrate adaptor activity |
| Molecular Function |
GO:0004842 |
ubiquitin-protein transferase activity |
| Biological Process |
GO:0031145 |
anaphase-promoting complex-dependent catabolic process |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007091 |
metaphase/anaphase transition of mitotic cell cycle |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0007080 |
mitotic metaphase chromosome alignment |
| Biological Process |
GO:0045842 |
positive regulation of mitotic metaphase/anaphase transition |
| Biological Process |
GO:0141198 |
protein branched polyubiquitination |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0070936 |
protein K48-linked ubiquitination |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0007096 |
regulation of exit from mitosis |
| Biological Process |
GO:0051445 |
regulation of meiotic cell cycle |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
| Biological Process |
GO:0030071 |
regulation of mitotic metaphase/anaphase transition |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.