Overview
| Uniprot ID | Q9UJX6 |
|---|
| Protein Name | Anaphase-promoting complex subunit 2 |
|---|
| Gene Name | ANAPC2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 362 |
RPAIEDLKYCLERTD |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:11739784, PubMed:18485873, PubMed:27120157, PubMed:27509861). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (PubMed:11739784, PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity)
Protein Sequence
10
MAAAVVVAEG
20
DSDSRPGQEL
30
LVAWNTVSTG
40
LVPPAALGLV
50
SSRTSGAVPP
60
KEEELRAAVE
70
VLRGHGLHSV
80
LEEWFVEVLQ
90
NDLQANISPE
100
FWNAISQCEN
110
SADEPQCLLL
120
LLDAFGLLES
130
RLDPYLRSLE
140
LLEKWTRLGL
150
LMGTGAQGLR
160
EEVHTMLRGV
170
LFFSTPRTFQ
180
EMIQRLYGCF
190
LRVYMQSKRK
200
GEGGTDPELE
210
GELDSRYARR
220
RYYRLLQSPL
230
CAGCSSDKQQ
240
CWCRQALEQF
250
HQLSQVLHRL
260
SLLERVSAEA
270
VTTTLHQVTR
280
ERMEDRCRGE
290
YERSFLREFH
300
KWIERVVGWL
310
GKVFLQDGPA
320
RPASPEAGNT
330
LRRWRCHVQR
340
FFYRIYASLR
350
IEELFSIVRD
360
FPDSRPAIED
370
LKYCLERTDQ
380
RQQLLVSLKA
390
ALETRLLHPG
400
VNTCDIITLY
410
ISAIKALRVL
420
DPSMVILEVA
430
CEPIRRYLRT
440
REDTVRQIVA
450
GLTGDSDGTG
460
DLAVELSKTD
470
PASLETGQDS
480
EDDSGEPEDW
490
VPDPVDADPG
500
KSSSKRRSSD
510
IISLLVSIYG
520
SKDLFINEYR
530
SLLADRLLHQ
540
FSFSPEREIR
550
NVELLKLRFG
560
EAPMHFCEVM
570
LKDMADSRRI
580
NANIREEDEK
590
RPAEEQPPFG
600
VYAVILSSEF
610
WPPFKDEKLE
620
VPEDIRAALE
630
AYCKKYEQLK
640
AMRTLSWKHT
650
LGLVTMDVEL
660
ADRTLSVAVT
670
PVQAVILLYF
680
QDQASWTLEE
690
LSKAVKMPVA
700
LLRRRMSVWL
710
QQGVLREEPP
720
GTFSVIEEER
730
PQDRDNMVLI
740
DSDDESDSGM
750
ASQADQKEEE
760
LLLFWTYIQA
770
MLTNLESLSL
780
DRIYNMLRMF
790
VVTGPALAEI
800
DLQELQGYLQ
810
KKVRDQQLVY
820
SAGVYRLPKN
CS
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0007399 |
nervous system development |
| Cellular Component |
GO:0005680 |
anaphase-promoting complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0031145 |
anaphase-promoting complex-dependent catabolic process |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007091 |
metaphase/anaphase transition of mitotic cell cycle |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0045773 |
positive regulation of axon extension |
| Biological Process |
GO:0050775 |
positive regulation of dendrite morphogenesis |
| Biological Process |
GO:0090129 |
positive regulation of synapse maturation |
| Biological Process |
GO:0031915 |
positive regulation of synaptic plasticity |
| Biological Process |
GO:0141198 |
protein branched polyubiquitination |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0070936 |
protein K48-linked ubiquitination |
| Biological Process |
GO:0051445 |
regulation of meiotic cell cycle |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.