Search Results
Overview
| Uniprot ID | Q9UJY5 |
|---|---|
| Protein Name | ADP-ribosylation factor-binding protein GGA1 |
| Gene Name | GGA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | KMLARLLKSSHPEDL |
Function
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016)
Protein Sequence
10
MEPAMEPETL
20
EARINRATNP
30
LNKELDWASI
40
NGFCEQLNED
50
FEGPPLATRL
60
LAHKIQSPQE
70
WEAIQALTVL
80
ETCMKSCGKR
90
FHDEVGKFRF
100
LNELIKVVSP
110
KYLGSRTSEK
120
VKNKILELLY
130
SWTVGLPEEV
140
KIAEAYQMLK
150
KQGIVKSDPK
160
LPDDTTFPLP
170
PPRPKNVIFE
180
DEEKSKMLAR
190
LLKSSHPEDL
200
RAANKLIKEM
210
VQEDQKRMEK
220
ISKRVNAIEE
230
VNNNVKLLTE
240
MVMSHSQGGA
250
AAGSSEDLMK
260
ELYQRCERMR
270
PTLFRLASDT
280
EDNDEALAEI
290
LQANDNLTQV
300
INLYKQLVRG
310
EEVNGDATAG
320
SIPGSTSALL
330
DLSGLDLPPA
340
GTTYPAMPTR
350
PGEQASPEQP
360
SASVSLLDDE
370
LMSLGLSDPT
380
PPSGPSLDGT
390
GWNSFQSSDA
400
TEPPAPALAQ
410
APSMESRPPA
420
QTSLPASSGL
430
DDLDLLGKTL
440
LQQSLPPESQ
450
QVRWEKQQPT
460
PRLTLRDLQN
470
KSSSCSSPSS
480
SATSLLHTVS
490
PEPPRPPQQP
500
VPTELSLASI
510
TVPLESIKPS
520
NILPVTVYDQ
530
HGFRILFHFA
540
RDPLPGRSDV
550
LVVVVSMLST
560
APQPIRNIVF
570
QSAVPKVMKV
580
KLQPPSGTEL
590
PAFNPIVHPS
600
AITQVLLLAN
610
PQKEKVRLRY
620
KLTFTMGDQT
630
YNEMGDVDQF
PPPETWGSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:0043001 | Golgi to plasma membrane protein transport |
| Biological Process | GO:0006893 | Golgi to plasma membrane transport |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0034394 | protein localization to cell surface |
| Biological Process | GO:1903441 | protein localization to ciliary membrane |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
Reference
PMID: N/A