Search Results
Overview
| Uniprot ID | Q9UK05 |
|---|---|
| Protein Name | Growth/differentiation factor 2 |
| Gene Name | GDF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | KMFLENVKVDFLRSL |
Function
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG
Protein Sequence
10
MCPGALWVAL
20
PLLSLLAGSL
30
QGKPLQSWGR
40
GSAGGNAHSP
50
LGVPGGGLPE
60
HTFNLKMFLE
70
NVKVDFLRSL
80
NLSGVPSQDK
90
TRVEPPQYMI
100
DLYNRYTSDK
110
STTPASNIVR
120
SFSMEDAISI
130
TATEDFPFQK
140
HILLFNISIP
150
RHEQITRAEL
160
RLYVSCQNHV
170
DPSHDLKGSV
180
VIYDVLDGTD
190
AWDSATETKT
200
FLVSQDIQDE
210
GWETLEVSSA
220
VKRWVRSDST
230
KSKNKLEVTV
240
ESHRKGCDTL
250
DISVPPGSRN
260
LPFFVVFSND
270
HSSGTKETRL
280
ELREMISHEQ
290
ESVLKKLSKD
300
GSTEAGESSH
310
EEDTDGHVAA
320
GSTLARRKRS
330
AGAGSHCQKT
340
SLRVNFEDIG
350
WDSWIIAPKE
360
YEAYECKGGC
370
FFPLADDVTP
380
TKHAIVQTLV
390
HLKFPTKVGK
400
ACCVPTKLSP
410
ISVLYKDDMG
420
VPTLKYHYEG
MSVAECGCR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0008083 | growth factor activity |
| Biological Process | GO:0032924 | activin receptor signaling pathway |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0048514 | blood vessel morphogenesis |
| Biological Process | GO:0030509 | BMP signaling pathway |
| Biological Process | GO:0001569 | branching involved in blood vessel morphogenesis |
| Biological Process | GO:0051216 | cartilage development |
| Biological Process | GO:0071773 | cellular response to BMP stimulus |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0008156 | negative regulation of DNA replication |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1903348 | positive regulation of bicellular tight junction assembly |
| Biological Process | GO:0030513 | positive regulation of BMP signaling pathway |
| Biological Process | GO:0061036 | positive regulation of cartilage development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045603 | positive regulation of endothelial cell differentiation |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0030858 | positive regulation of epithelial cell differentiation |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0045747 | positive regulation of Notch signaling pathway |
| Biological Process | GO:0060391 | positive regulation of SMAD protein signal transduction |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001570 | vasculogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.