Search Results
Overview
| Uniprot ID | Q9UK32 |
|---|---|
| Protein Name | Ribosomal protein S6 kinase alpha-6 |
| Gene Name | RPS6KA6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | DVFTRLSKEVLFTEE |
Function
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis
Protein Sequence
10
MLPFAPQDEP
20
WDREMEVFSG
30
GGASSGEVNG
40
LKMVDEPMEE
50
GEADSCHDEG
60
VVKEIPITHH
70
VKEGYEKADP
80
AQFELLKVLG
90
QGSFGKVFLV
100
RKKTGPDAGQ
110
LYAMKVLKKA
120
SLKVRDRVRT
130
KMERDILVEV
140
NHPFIVKLHY
150
AFQTEGKLYL
160
ILDFLRGGDV
170
FTRLSKEVLF
180
TEEDVKFYLA
190
ELALALDHLH
200
QLGIVYRDLK
210
PENILLDEIG
220
HIKLTDFGLS
230
KESVDQEKKA
240
YSFCGTVEYM
250
APEVVNRRGH
260
SQSADWWSYG
270
VLMFEMLTGT
280
LPFQGKDRNE
290
TMNMILKAKL
300
GMPQFLSAEA
310
QSLLRMLFKR
320
NPANRLGSEG
330
VEEIKRHLFF
340
ANIDWDKLYK
350
REVQPPFKPA
360
SGKPDDTFCF
370
DPEFTAKTPK
380
DSPGLPASAN
390
AHQLFKGFSF
400
VATSIAEEYK
410
ITPITSANVL
420
PIVQINGNAA
430
QFGEVYELKE
440
DIGVGSYSVC
450
KRCIHATTNM
460
EFAVKIIDKS
470
KRDPSEEIEI
480
LMRYGQHPNI
490
ITLKDVFDDG
500
RYVYLVTDLM
510
KGGELLDRIL
520
KQKCFSEREA
530
SDILYVISKT
540
VDYLHCQGVV
550
HRDLKPSNIL
560
YMDESASADS
570
IRICDFGFAK
580
QLRGENGLLL
590
TPCYTANFVA
600
PEVLMQQGYD
610
AACDIWSLGV
620
LFYTMLAGYT
630
PFANGPNDTP
640
EEILLRIGNG
650
KFSLSGGNWD
660
NISDGAKDLL
670
SHMLHMDPHQ
680
RYTAEQILKH
690
SWITHRDQLP
700
NDQPKRNDVS
710
HVVKGAMVAT
720
YSALTHKTFQ
730
PVLEPVAASS
740
LAQRRSMKKR
TSTGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004711 | ribosomal protein S6 kinase activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0045992 | negative regulation of embryonic development |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000381 | negative regulation of mesoderm development |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0038202 | TORC1 signaling |
Reference
PMID: N/A