Search Results
Overview
| Uniprot ID | Q9UK45 |
|---|---|
| Protein Name | U6 snRNA-associated Sm-like protein LSm7 |
| Gene Name | LSM7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 9 | ADKEKKKKESILDLS |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166, PubMed:35047835). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320)
Protein Sequence
10
MADKEKKKKE
20
SILDLSKYID
30
KTIRVKFQGG
40
REASGILKGF
50
DPLLNLVLDG
60
TIEYMRDPDD
70
QYKLTEDTRQ
80
LGLVVCRGTS
90
VVLICPQDGM
100
EAIPNPFIQQ
QDA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Cellular Component | GO:0120115 | Lsm2-8 complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Cellular Component | GO:0005689 | U12-type spliceosomal complex |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0071004 | U2-type prespliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005688 | U6 snRNP |
| Molecular Function | GO:0017070 | U6 snRNA binding |
| Biological Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.