Search Results
Overview
| Uniprot ID | Q9UK53 |
|---|---|
| Protein Name | Inhibitor of growth protein 1 |
| Gene Name | ING1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 278 | KAGADRPKGEAAAQA |
| 291 | QADKPNSKRSRRQRN |
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene
Protein Sequence
10
MSFVECPYHS
20
PAERLVAEAD
30
EGGPSAITGM
40
GLCFRCLLFS
50
FSGRSGVEGG
60
RVDLNVFGSL
70
GLQPWIGSSR
80
CWGGPCSSAL
90
RCGWFSSWPP
100
PSKSAIPIGG
110
GSRGAGRVSR
120
WPPPHWLEAW
130
RVSPLPLSPL
140
SPATFGRGFI
150
AVAVIPGLWA
160
RGRGCSSDRL
170
PRPAGPARRQ
180
FQAASLLTRG
190
WGRAWPWKQI
200
LKELDECYER
210
FSRETDGAQK
220
RRMLHCVQRA
230
LIRSQELGDE
240
KIQIVSQMVE
250
LVENRTRQVD
260
SHVELFEAQQ
270
ELGDTAGNSG
280
KAGADRPKGE
290
AAAQADKPNS
300
KRSRRQRNNE
310
NRENASSNHD
320
HDDGASGTPK
330
EKKAKTSKKK
340
KRSKAKAERE
350
ASPADLPIDP
360
NEPTYCLCNQ
370
VSYGEMIGCD
380
NDECPIEWFH
390
FSCVGLNHKP
400
KGKWYCPKCR
410
GENEKTMDKA
420
LEKSKKERAY
NR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0140002 | histone H3K4me3 reader activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:1902455 | negative regulation of stem cell population maintenance |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.