Search Results
Overview
| Uniprot ID | Q9UK58 |
|---|---|
| Protein Name | Cyclin-L1 |
| Gene Name | CCNL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 362 | SINVKTVKKEPEDRQ |
Function
Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing (PubMed:11980906, PubMed:18216018, PubMed:38059508). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036)
Protein Sequence
10
MASGPHSTAT
20
AAAAASSAAP
30
SAGGSSSGTT
40
TTTTTTTGGI
50
LIGDRLYSEV
60
SLTIDHSLIP
70
EERLSPTPSM
80
QDGLDLPSET
90
DLRILGCELI
100
QAAGILLRLP
110
QVAMATGQVL
120
FHRFFYSKSF
130
VKHSFEIVAM
140
ACINLASKIE
150
EAPRRIRDVI
160
NVFHHLRQLR
170
GKRTPSPLIL
180
DQNYINTKNQ
190
VIKAERRVLK
200
ELGFCVHVKH
210
PHKIIVMYLQ
220
VLECERNQTL
230
VQTAWNYMND
240
SLRTNVFVRF
250
QPETIACACI
260
YLAARALQIP
270
LPTRPHWFLL
280
FGTTEEEIQE
290
ICIETLRLYT
300
RKKPNYELLE
310
KEVEKRKVAL
320
QEAKLKAKGL
330
NPDGTPALST
340
LGGFSPASKP
350
SSPREVKAEE
360
KSPISINVKT
370
VKKEPEDRQQ
380
ASKSPYNGVR
390
KDSKRSRNSR
400
SASRSRSRTR
410
SRSRSHTPRR
420
HYNNRRSRSG
430
TYSSRSRSRS
440
RSHSESPRRH
450
HNHGSPHLKA
460
KHTRDDLKSS
470
NRHGHKRKKS
480
RSRSQSKSRD
490
HSDAAKKHRH
500
ERGHHRDRRE
510
RSRSFERSHK
520
SKHHGGSRSG
HGRHRR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0180038 | cyclin L-CDK11 complex |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0046605 | regulation of centrosome cycle |
| Biological Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0008380 | RNA splicing |
Reference
PMID: N/A