Search Results
Overview
| Uniprot ID | Q9UK59 |
|---|---|
| Protein Name | Lariat debranching enzyme |
| Gene Name | DBR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 186 | SIYHYGNKKQLLKTK |
| 187 | IYHYGNKKQLLKTKS |
Function
Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921)
Protein Sequence
10
MRVAVAGCCH
20
GELDKIYETL
30
ALAERRGPGP
40
VDLLLCCGDF
50
QAVRNEADLR
60
CMAVPPKYRH
70
MQTFYRYYSG
80
EKKAPVLTLF
90
IGGNHEASNH
100
LQELPYGGWV
110
APNIYYLGLA
120
GVVKYRGVRI
130
GGISGIFKSH
140
DYRKGHFECP
150
PYNSSTIRSI
160
YHVRNIEVYK
170
LKQLKQPIDI
180
FLSHDWPRSI
190
YHYGNKKQLL
200
KTKSFFRQEV
210
ENNTLGSPAA
220
SELLEHLKPT
230
YWFSAHLHVK
240
FAALMQHQAK
250
DKGQTARATK
260
FLALDKCLPH
270
RDFLQILEIE
280
HDPSAPDYLE
290
YDIEWLTILR
300
ATDDLINVTG
310
RLWNMPENNG
320
LHARWDYSAT
330
EEGMKEVLEK
340
LNHDLKVPCN
350
FSVTAACYDP
360
SKPQTQMQLI
370
HRINPQTTEF
380
CAQLGIIDIN
390
VRLQKSKEEH
400
HVCGEYEEQD
410
DVESNDSGED
420
QSEYNTDTSA
430
LSSINPDEIM
440
LDEEEDEDSI
450
VSAHSGMNTP
460
SVEPSDQASE
470
FSASFSDVRI
480
LPGSMIVSSD
490
DTVDSTIDRE
500
GKPGGTVESG
510
NGEDLTKVPL
520
KRLSDEHEPE
530
QRKKIKRRNQ
540
AIYAAVDDDD
DDAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008419 | RNA lariat debranching enzyme activity |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0000292 | RNA fragment catabolic process |
| Biological Process | GO:0000375 | RNA splicing, via transesterification reactions |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.