Search Results
Overview
| Uniprot ID | Q9UK85 |
|---|---|
| Protein Name | Dickkopf-like protein 1 |
| Gene Name | DKKL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 229 | HSRLSPRKTHLLYIL |
Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility
Protein Sequence
10
MGEASPPAPA
20
RRHLLVLLLL
30
LSTLVIPSAA
40
APIHDADAQE
50
SSLGLTGLQS
60
LLQGFSRLFL
70
KGNLLRGIDS
80
LFSAPMDFRG
90
LPGNYHKEEN
100
QEHQLGNNTL
110
SSHLQIDKMT
120
DNKTGEVLIS
130
ENVVASIQPA
140
EGSFEGDLKV
150
PRMEEKEALV
160
PIQKATDSFH
170
TELHPRVAFW
180
IIKLPRRRSH
190
QDALEGGHWL
200
SEKRHRLQAI
210
RDGLRKGTHK
220
DVLEEGTESS
230
SHSRLSPRKT
240
HLLYILRPSR
QL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0039706 | co-receptor binding |
| Molecular Function | GO:0048019 | receptor antagonist activity |
| Biological Process | GO:0009653 | anatomical structure morphogenesis |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:2000225 | negative regulation of testosterone biosynthetic process |
| Biological Process | GO:0007341 | penetration of zona pellucida |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.