Search Results
Overview
| Uniprot ID | Q9UKA9 |
|---|---|
| Protein Name | Polypyrimidine tract-binding protein 2 |
| Gene Name | PTBP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 411 | IIRVTLSKHQTVQLP |
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation
Protein Sequence
10
MDGIVTEVAV
20
GVKRGSDELL
30
SGSVLSSPNS
40
NMSSMVVTAN
50
GNDSKKFKGE
60
DKMDGAPSRV
70
LHIRKLPGEV
80
TETEVIALGL
90
PFGKVTNILM
100
LKGKNQAFLE
110
LATEEAAITM
120
VNYYSAVTPH
130
LRNQPIYIQY
140
SNHKELKTDN
150
TLNQRAQAVL
160
QAVTAVQTAN
170
TPLSGTTVSE
180
SAVTPAQSPV
190
LRIIIDNMYY
200
PVTLDVLHQI
210
FSKFGAVLKI
220
ITFTKNNQFQ
230
ALLQYGDPVN
240
AQQAKLALDG
250
QNIYNACCTL
260
RIDFSKLVNL
270
NVKYNNDKSR
280
DYTRPDLPSG
290
DGQPALDPAI
300
AAAFAKETSL
310
LAVPGALSPL
320
AIPNAAAAAA
330
AAAAGRVGMP
340
GVSAGGNTVL
350
LVSNLNEEMV
360
TPQSLFTLFG
370
VYGDVQRVKI
380
LYNKKDSALI
390
QMADGNQSQL
400
AMNHLNGQKM
410
YGKIIRVTLS
420
KHQTVQLPRE
430
GLDDQGLTKD
440
FGNSPLHRFK
450
KPGSKNFQNI
460
FPPSATLHLS
470
NIPPSVAEED
480
LRTLFANTGG
490
TVKAFKFFQD
500
HKMALLQMAT
510
VEEAIQALID
520
LHNYNLGENH
530
HLRVSFSKST
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0033119 | negative regulation of RNA splicing |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0021510 | spinal cord development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.