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Overview

Uniprot IDQ9UKB3
Protein NameDnaJ homolog subfamily C member 12
Gene NameDNAJC12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
183 HLRFRWSKDAPSELL

Function

Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2)

Protein Sequence

10 MDAILNYRSE 20 DTEDYYTLLG 30 CDELSSVEQI 40 LAEFKVRALE 50 CHPDKHPENP 60 KAVETFQKLQ 70 KAKEILTNEE 80 SRARYDHWRR 90 SQMSMPFQQW 100 EALNDSVKTS 110 MHWVVRGKKD 120 LMLEESDKTH 130 TTKMENEECN 140 EQRERKKEEL 150 ASTAEKTEQK 160 EPKPLEKSVS 170 PQNSDSSGFA 180 DVNGWHLRFR 190 WSKDAPSELL RKFRNYEI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.