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Overview

Uniprot IDQ9UKG9
Protein NamePeroxisomal carnitine O-octanoyltransferase
Gene NameCROT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
65 FQSGIGEKLHQKLLE

Function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester

Protein Sequence

10 MENQLAKSTE 20 ERTFQYQDSL 30 PSLPVPSLEE 40 SLKKYLESVK 50 PFANQEEYKK 60 TEEIVQKFQS 70 GIGEKLHQKL 80 LERAKGKRNW 90 LEEWWLNVAY 100 LDVRIPSQLN 110 VNFAGPAAHF 120 EHYWPPKEGT 130 QLERGSITLW 140 HNLNYWQLLR 150 KEKVPVHKVG 160 NTPLDMNQFR 170 MLFSTCKVPG 180 ITRDSIMNYF 190 RTESEGRSPN 200 HIVVLCRGRA 210 FVFDVIHEGC 220 LVTPPELLRQ 230 LTYIHKKCHS 240 EPDGPGIAAL 250 TSEERTRWAK 260 AREYLIGLDP 270 ENLALLEKIQ 280 SSLLVYSMED 290 SSPHVTPEDY 300 SEIIAAILIG 310 DPTVRWGDKS 320 YNLISFSNGV 330 FGCNCDHAPF 340 DAMIMVNISY 350 YVDEKIFQNE 360 GRWKGSEKVR 370 DIPLPEELIF 380 IVDEKVLNDI 390 NQAKAQYLRE 400 ASDLQIAAYA 410 FTSFGKKLTK 420 NKMLHPDTFI 430 QLALQLAYYR 440 LHGHPGCCYE 450 TAMTRHFYHG 460 RTETMRSCTV 470 EAVRWCQSMQ 480 DPSVNLRERQ 490 QKMLQAFAKH 500 NKMMKDCSAG 510 KGFDRHLLGL 520 LLIAKEEGLP 530 VPELFTDPLF 540 SKSGGGGNFV 550 LSTSLVGYLR 560 VQGVVVPMVH 570 NGYGFFYHIR 580 DDRFVVACSA 590 WKSCPETDAE 600 KLVQLTFCAF 610 HDMIQLMNST HL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0008458 carnitine O-octanoyltransferase activity
Biological Process GO:0009437 carnitine metabolic process
Biological Process GO:0015936 coenzyme A metabolic process
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0051791 medium-chain fatty acid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.