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Overview

Uniprot ID	Q9UKI8
Protein Name	Serine/threonine-protein kinase tousled-like 1
Gene Name	TLK1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
137	QNESSQGKSIGGRGH

Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'

Protein Sequence

10 MSVQSSSGSL 20 EGPPSWSQLS 30 TSPTPGSAAA 40 ARSLLNHTPP 50 SGRPREGAMD 60 ELHSLDPRRQ 70 ELLEARFTGV 80 ASGSTGSTGS 90 CSVGAKASTN 100 NESSNHSFGS 110 LGSLSDKESE 120 TPEKKQSESS 130 RGRKRKAENQ 140 NESSQGKSIG 150 GRGHKISDYF 160 EYQGGNGSSP 170 VRGIPPAIRS 180 PQNSHSHSTP 190 SSSVRPNSPS 200 PTALAFGDHP 210 IVQPKQLSFK 220 IIQTDLTMLK 230 LAALESNKIQ 240 DLEKKEGRID 250 DLLRANCDLR 260 RQIDEQQKLL 270 EKYKERLNKC 280 ISMSKKLLIE 290 KSTQEKLSSR 300 EKSMQDRLRL 310 GHFTTVRHGA 320 SFTEQWTDGF 330 AFQNLVKQQE 340 WVNQQREDIE 350 RQRKLLAKRK 360 PPTANNSQAP 370 STNSEPKQRK 380 NKAVNGAEND 390 PFVRPNLPQL 400 LTLAEYHEQE 410 EIFKLRLGHL 420 KKEEAEIQAE 430 LERLERVRNL 440 HIRELKRINN 450 EDNSQFKDHP 460 TLNERYLLLH 470 LLGRGGFSEV 480 YKAFDLYEQR 490 YAAVKIHQLN 500 KSWRDEKKEN 510 YHKHACREYR 520 IHKELDHPRI 530 VKLYDYFSLD 540 TDTFCTVLEY 550 CEGNDLDFYL 560 KQHKLMSEKE 570 ARSIVMQIVN 580 ALRYLNEIKP 590 PIIHYDLKPG 600 NILLVDGTAC 610 GEIKITDFGL 620 SKIMDDDSYG 630 VDGMDLTSQG 640 AGTYWYLPPE 650 CFVVGKEPPK 660 ISNKVDVWSV 670 GVIFFQCLYG 680 RKPFGHNQSQ 690 QDILQENTIL 700 KATEVQFPVK 710 PVVSSEAKAF 720 IRRCLAYRKE 730 DRFDVHQLAN 740 DPYLLPHMRR 750 SNSSGNLHMA 760 GLTASPTPPS SSIITY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0007059	chromosome segregation
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:1902275	regulation of chromatin organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.