Search Results

Overview

Uniprot IDQ9UKJ3
Protein NameG patch domain-containing protein 8
Gene NameGPATCH8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1096 TAKLLLEKIQSRKVE
1118 EVQATPNKAGPKLKD
1160 ATRKPNKKCEESGLE
127 DKEKAIAKALEDLRA
1322 EEMEKYSKLQQAAQQ
447 PKPKSCIKAAASQGA
621 SKEVGGEKIVRSSGG

Function

No function data available.

Protein Sequence

10 MADRFSRFNE 20 DRDFQGNHFD 30 QYEEGHLEIE 40 QASLDKPIES 50 DNIGHRLLQK 60 HGWKLGQGLG 70 KSLQGRTDPI 80 PIVVKYDVMG 90 MGRMEMELDY 100 AEDATERRRV 110 LEVEKEDTEE 120 LRQKYKDYVD 130 KEKAIAKALE 140 DLRANFYCEL 150 CDKQYQKHQE 160 FDNHINSYDH 170 AHKQRLKDLK 180 QREFARNVSS 190 RSRKDEKKQE 200 KALRRLHELA 210 EQRKQAECAP 220 GSGPMFKPTT 230 VAVDEEGGED 240 DKDESATNSG 250 TGATASCGLG 260 SEFSTDKGGP 270 FTAVQITNTT 280 GLAQAPGLAS 290 QGISFGIKNN 300 LGTPLQKLGV 310 SFSFAKKAPV 320 KLESIASVFK 330 DHAEEGTSED 340 GTKPDEKSSD 350 QGLQKVGDSD 360 GSSNLDGKKE 370 DEDPQDGGSL 380 ASTLSKLKRM 390 KREEGAGATE 400 PEYYHYIPPA 410 HCKVKPNFPF 420 LLFMRASEQM 430 DGDNTTHPKN 440 APESKKGSSP 450 KPKSCIKAAA 460 SQGAEKTVSE 470 VSEQPKETSM 480 TEPSEPGSKA 490 EAKKALGGDV 500 SDQSLESHSQ 510 KVSETQMCES 520 NSSKETSLAT 530 PAGKESQEGP 540 KHPTGPFFPV 550 LSKDESTALQ 560 WPSELLIFTK 570 AEPSISYSCN 580 PLYFDFKLSR 590 NKDARTKGTE 600 KPKDIGSSSK 610 DHLQGLDPGE 620 PNKSKEVGGE 630 KIVRSSGGRM 640 DAPASGSACS 650 GLNKQEPGGS 660 HGSETEDTGR 670 SLPSKKERSG 680 KSHRHKKKKK 690 HKKSSKHKRK 700 HKADTEEKSS 710 KAESGEKSKK 720 RKKRKRKKNK 730 SSAPADSERG 740 PKPEPPGSGS 750 PAPPRRRRRA 760 QDDSQRRSLP 770 AEEGSSGKKD 780 EGGGGSSSQD 790 HGGRKHKGEL 800 PPSSCQRRAG 810 TKRSSRSSHR 820 SQPSSGDEDS 830 DDASSHRLHQ 840 KSPSQYSEEE 850 EEEDSGSEHS 860 RSRSRSGRRH 870 SSHRSSRRSY 880 SSSSDASSDQ 890 SCYSRQRSYS 900 DDSYSDYSDR 910 SRRHSKRSHD 920 SDDSDYASSK 930 HRSKRHKYSS 940 SDDDYSLSCS 950 QSRSRSRSHT 960 RERSRSRGRS 970 RSSSCSRSRS 980 KRRSRSTTAH 990 SWQRSRSYSR 1000 DRSRSTRSPS 1010 QRSGSRKRSW 1020 GHESPEERHS 1030 GRRDFIRSKI 1040 YRSQSPHYFR 1050 SGRGEGPGKK 1060 DDGRGDDSKA 1070 TGPPSQNSNI 1080 GTGRGSEGDC 1090 SPEDKNSVTA 1100 KLLLEKIQSR 1110 KVERKPSVSE 1120 EVQATPNKAG 1130 PKLKDPPQGY 1140 FGPKLPPSLG 1150 NKPVLPLIGK 1160 LPATRKPNKK 1170 CEESGLERGE 1180 EQEQSETEEG 1190 PPGSSDALFG 1200 HQFPSEETTG 1210 PLLDPPPEES 1220 KSGEATADHP 1230 VAPLGTPAHS 1240 DCYPGDPTIS 1250 HNYLPDPSDG 1260 DTLESLDSSS 1270 QPGPVESSLL 1280 PIAPDLEHFP 1290 SYAPPSGDPS 1300 IESTDGAEDA 1310 SLAPLESQPI 1320 TFTPEEMEKY 1330 SKLQQAAQQH 1340 IQQQLLAKQV 1350 KAFPASAALA 1360 PATPALQPIH 1370 IQQPATASAT 1380 SITTVQHAIL 1390 QHHAAAAAAA 1400 IGIHPHPHPQ 1410 PLAQVHHIPQ 1420 PHLTPISLSH 1430 LTHSIIPGHP 1440 ATFLASHPIH 1450 IIPASAIHPG 1460 PFTFHPVPHA 1470 ALYPTLLAPR 1480 PAAAAATALH 1490 LHPLLHPIFS 1500 GQDLQHPPSH GT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.