Search Results

Overview

Uniprot IDQ9UKK3
Protein NameProtein mono-ADP-ribosyltransferase PARP4
Gene NamePARP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
345 VNLGLLAKKADLCQL
381 KYRALRCKIEHVEQN

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379). Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (PubMed:40691181)

Protein Sequence

10 MVMGIFANCI 20 FCLKVKYLPQ 30 QQKKKLQTDI 40 KENGGKFSFS 50 LNPQCTHIIL 60 DNADVLSQYQ 70 LNSIQKNHVH 80 IANPDFIWKS 90 IREKRLLDVK 100 NYDPYKPLDI 110 TPPPDQKASS 120 SEVKTEGLCP 130 DSATEEEDTV 140 ELTEFGMQNV 150 EIPHLPQDFE 160 VAKYNTLEKV 170 GMEGGQEAVV 180 VELQCSRDSR 190 DCPFLISSHF 200 LLDDGMETRR 210 QFAIKKTSED 220 ASEYFENYIE 230 ELKKQGFLLR 240 EHFTPEATQL 250 ASEQLQALLL 260 EEVMNSSTLS 270 QEVSDLVEMI 280 WAEALGHLEH 290 MLLKPVNRIS 300 LNDVSKAEGI 310 LLLVKAALKN 320 GETAEQLQKM 330 MTEFYRLIPH 340 KGTMPKEVNL 350 GLLAKKADLC 360 QLIRDMVNVC 370 ETNLSKPNPP 380 SLAKYRALRC 390 KIEHVEQNTE 400 EFLRVRKEVL 410 QNHHSKSPVD 420 VLQIFRVGRV 430 NETTEFLSKL 440 GNVRPLLHGS 450 PVQNIVGILC 460 RGLLLPKVVE 470 DRGVQRTDVG 480 NLGSGIYFSD 490 SLSTSIKYSH 500 PGETDGTRLL 510 LICDVALGKC 520 MDLHEKDFSL 530 TEAPPGYDSV 540 HGVSQTASVT 550 TDFEDDEFVV 560 YKTNQVKMKY 570 IIKFSMPGDQ 580 IKDFHPSDHT 590 ELEEYRPEFS 600 NFSKVEDYQL 610 PDAKTSSSTK 620 AGLQDASGNL 630 VPLEDVHIKG 640 RIIDTVAQVI 650 VFQTYTNKSH 660 VPIEAKYIFP 670 LDDKAAVCGF 680 EAFINGKHIV 690 GEIKEKEEAQ 700 QEYLEAVTQG 710 HGAYLMSQDA 720 PDVFTVSVGN 730 LPPKAKVLIK 740 ITYITELSIL 750 GTVGVFFMPA 760 TVAPWQQDKA 770 LNENLQDTVE 780 KICIKEIGTK 790 QSFSLTMSIE 800 MPYVIEFIFS 810 DTHELKQKRT 820 DCKAVISTME 830 GSSLDSSGFS 840 LHIGLSAAYL 850 PRMWVEKHPE 860 KESEACMLVF 870 QPDLDVDLPD 880 LASESEVIIC 890 LDCSSSMEGV 900 TFLQAKQIAL 910 HALSLVGEKQ 920 KVNIIQFGTG 930 YKELFSYPKH 940 ITSNTMAAEF 950 IMSATPTMGN 960 TDFWKTLRYL 970 SLLYPARGSR 980 NILLVSDGHL 990 QDESLTLQLV 1000 KRSRPHTRLF 1010 ACGIGSTANR 1020 HVLRILSQCG 1030 AGVFEYFNAK 1040 SKHSWRKQIE 1050 DQMTRLCSPS 1060 CHSVSVKWQQ 1070 LNPDVPEALQ 1080 APAQVPSLFL 1090 NDRLLVYGFI 1100 PHCTQATLCA 1110 LIQEKEFRTM 1120 VSTTELQKTT 1130 GTMIHKLAAR 1140 ALIRDYEDGI 1150 LHENETSHEM 1160 KKQTLKSLII 1170 KLSKENSLIT 1180 QFTSFVAVEK 1190 RDENESPFPD 1200 IPKVSELIAK 1210 EDVDFLPYMS 1220 WQGEPQEAVR 1230 NQSLLASSEW 1240 PELRLSKRKH 1250 RKIPFSKRKM 1260 ELSQPEVSED 1270 FEEDGLGVLP 1280 AFTSNLERGG 1290 VEKLLDLSWT 1300 ESCKPTATEP 1310 LFKKVSPWET 1320 STSSFFPILA 1330 PAVGSYLPPT 1340 ARAHSPASLS 1350 FASYRQVASF 1360 GSAAPPRQFD 1370 ASQFSQGPVP 1380 GTCADWIPQS 1390 ASCPTGPPQN 1400 PPSSPYCGIV 1410 FSGSSLSSAQ 1420 SAPLQHPGGF 1430 TTRPSAGTFP 1440 ELDSPQLHFS 1450 LPTDPDPIRG 1460 FGSYHPSASS 1470 PFHFQPSAAS 1480 LTANLRLPMA 1490 SALPEALCSQ 1500 SRTTPVDLCL 1510 LEESVGSLEG 1520 SRCPVFAFQS 1530 SDTESDELSE 1540 VLQDSCFLQI 1550 KCDTKDDSIL 1560 CFLEVKEEDE 1570 IVCIQHWQDA 1580 VPWTELLSLQ 1590 TEDGFWKLTP 1600 ELGLILNLNT 1610 NGLHSFLKQK 1620 GIQSLGVKGR 1630 ECLLDLIATM 1640 LVLQFIRTRL 1650 EKEGIVFKSL 1660 MKMDDASISR 1670 NIPWAFEAIK 1680 QASEWVRRTE 1690 GQYPSICPRL 1700 ELGNDWDSAT 1710 KQLLGLQPIS 1720 TVSPLHRVLH YSQG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005876 spindle microtubule
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0003950 NAD+ poly-ADP-ribosyltransferase activity
Molecular Function GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity
Molecular Function GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
Molecular Function GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity
Molecular Function GO:0016779 nucleotidyltransferase activity
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0006954 inflammatory response
Biological Process GO:0036211 protein modification process
Biological Process GO:0015031 protein transport
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.