Search Results

Overview

Uniprot IDQ9UKL0
Protein NameREST corepressor 1
Gene NameRCOR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 KGPEVSGKRRGRNNA
242 SWKKTRTKTSVMDRH
285 DQNKESKKEVPPTET
297 TETVPQVKKEKHSTQ
298 ETVPQVKKEKHSTQA
349 DMELVSVKRQIQNIK
356 KRQIQNIKQTNSALK
365 TNSALKEKLDGGIEP
381 RLPEVIQKCNARWTT
459 PSNQKPVKSPDNSIK
466 KSPDNSIKMPEEEDE
7 *MPAMVEKGPEVSGK

Function

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation

Protein Sequence

10 MPAMVEKGPE 20 VSGKRRGRNN 30 AAASASAAAA 40 SAAASAACAS 50 PAATAASGAA 60 ASSASAAAAS 70 AAAAPNNGQN 80 KSLAAAAPNG 90 NSSSNSWEEG 100 SSGSSSDEEH 110 GGGGMRVGPQ 120 YQAVVPDFDP 130 AKLARRSQER 140 DNLGMLVWSP 150 NQNLSEAKLD 160 EYIAIAKEKH 170 GYNMEQALGM 180 LFWHKHNIEK 190 SLADLPNFTP 200 FPDEWTVEDK 210 VLFEQAFSFH 220 GKTFHRIQQM 230 LPDKSIASLV 240 KFYYSWKKTR 250 TKTSVMDRHA 260 RKQKREREES 270 EDELEEANGN 280 NPIDIEVDQN 290 KESKKEVPPT 300 ETVPQVKKEK 310 HSTQAKNRAK 320 RKPPKGMFLS 330 QEDVEAVSAN 340 ATAATTVLRQ 350 LDMELVSVKR 360 QIQNIKQTNS 370 ALKEKLDGGI 380 EPYRLPEVIQ 390 KCNARWTTEE 400 QLLAVQAIRK 410 YGRDFQAISD 420 VIGNKSVVQV 430 KNFFVNYRRR 440 FNIDEVLQEW 450 EAEHGKEETN 460 GPSNQKPVKS 470 PDNSIKMPEE 480 EDEAPVLDVR YASAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990391 DNA repair complex
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045654 positive regulation of megakaryocyte differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.