Search Results

Overview

Uniprot ID	Q9UKL3
Protein Name	CASP8-associated protein 2
Gene Name	CASP8AP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1206	SEDPVHYKSLVGCKK

Function

Participates in TNF-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B (PubMed:12477726, PubMed:15698540). Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (PubMed:12477726, PubMed:15698540). Involved in TNF-induced activation of NF-kappa-B via a TRAF2-dependent pathway (By similarity). Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B (PubMed:17245429). Required for the activation of CASP8 in FAS-mediated apoptosis (PubMed:17245429). Involved for histone gene transcription and progression through S phase: required for the generation of mature histone mRNAs following the 3' end cleavage of histone pre-mRNAs (PubMed:17003125, PubMed:19854135, PubMed:32367068)

Protein Sequence

10 MAADDDNGDG 20 TSLFDVFSAS 30 PLKNNDEGSL 40 DIYAGLDSAV 50 SDSASKSCVP 60 SRNCLDLYEE 70 ILTEEGTAKE 80 ATYNDLQVEY 90 GKCQLQMKEL 100 MKKFKEIQTQ 110 NFSLINENQS 120 LKKNISALIK 130 TARVEINRKD 140 EEISNLHQRL 150 SEFPHFRNNH 160 KTARTFDTVK 170 TKDLKSRSPH 180 LDDCSKTDHR 190 AKSDVSKDVH 200 HSTSLPNLEK 210 EGKPHSDKRS 220 TSHLPTSVEK 230 HCTNGVWSRS 240 HYQVGEGSSN 250 EDSRRGRKDI 260 RHSQFNRGTE 270 RVRKDLSTGC 280 GDGEPRILEA 290 SQRLQGHPEK 300 YGKGEPKTES 310 KSSKFKSNSD 320 SDYKGERINS 330 SWEKETPGER 340 SHSRVDSQSD 350 KKLERQSERS 360 QNINRKEVKS 370 QDKEERKVDQ 380 KPKSVVKDQD 390 HWRRSERASL 400 PHSKNEITFS 410 HNSSKYHLEE 420 RRGWEDCKRD 430 KSVNSHSFQD 440 GRCPSSLSNS 450 RTHKNIDSKE 460 VDAMHQWENT 470 PLKAERHRTE 480 DKRKREQESK 490 EENRHIRNEK 500 RVPTEHLQKT 510 NKETKKTTTD 520 LKKQNEPKTD 530 KGEVLDNGVS 540 EGADNKELAM 550 KAESGPNETK 560 NKDLKLSFMK 570 KLNLTLSPAK 580 KQPVSQDNQH 590 KITDIPKSSG 600 VCDSESSMQV 610 KTVAYVPSIS 620 EHILGEAAVS 630 EHTMGETKST 640 LLEPKVALLA 650 VTEPRIGISE 660 TNKEDENSLL 670 VRSVDNTMHC 680 EEPICGTETS 690 FPSPMEIQQT 700 ESLFPSTGMK 710 QTINNGRAAA 720 PVVMDVLQTD 730 VSQNFGLELD 740 TKRNDNSDYC 750 GISEGMEMKV 760 ALSTTVSETT 770 ESILQPSIEE 780 ADILPIMLSE 790 DNNPKFEPSV 800 IVTPLVESKS 810 CHLEPCLPKE 820 TLDSSLQQTE 830 LMDHRMATGE 840 TNSVYHDDDN 850 SVLSIDLNHL 860 RPIPEAISPL 870 NSPVRPVAKV 880 LRNESPPQVP 890 VYNNSHKDVF 900 LPNSAHSTSK 910 SQSDLNKENQ 920 KPIYKSDKCT 930 EADTCKNSPL 940 DELEEGEIRS 950 DSETSKPQES 960 FEKNSKRRVS 970 ADVRKSKTIP 980 RRGKSTVCLD 990 KDSRKTHVRI 1000 HQTNNKWNKR 1010 PDKSSRSSKT 1020 EKKDKVMSTS 1030 SLEKIVPIIA 1040 VPSSEQEIMH 1050 MLRMIRKHVR 1060 KNYMKFKAKF 1070 SLIQFHRIIE 1080 SAILSFTSLI 1090 KHLNLHKISK 1100 SVTTLQKNLC 1110 DIIESKLKQV 1120 KKNGIVDRLF 1130 EQQLPDMKKK 1140 LWKFVDDQLD 1150 YLFAKLKKIL 1160 VCDSKSFGRD 1170 SDEGKLEKTS 1180 KQNAQYSNSQ 1190 KRSVDNSNRE 1200 LLKEKLSKSE 1210 DPVHYKSLVG 1220 CKKSEENYQD 1230 QNNSSINTVK 1240 HDIKKNFNIC 1250 FDNIKNSQSE 1260 ERSLEVHCPS 1270 TPKSEKNEGS 1280 SIEDAQTSQH 1290 ATLKPERSFE 1300 ILTEQQASSL 1310 TFNLVSDAQM 1320 GEIFKSLLQG 1330 SDLLDSSVNC 1340 TEKSEWELKT 1350 PEKQLLETLK 1360 CESIPACTTE 1370 ELVSGVASPC 1380 PKMISDDNWS 1390 LLSSEKGPSL 1400 SSGLSLPVHP 1410 DVLDESCMFE 1420 VSTNLPLSKD 1430 NVCSVEKSKP 1440 CVSSILLEDL 1450 AVSLTVPSPL 1460 KSDGHLSFLK 1470 PDMSSSSTPE 1480 EVISAHFSED 1490 ALLEEEDASE 1500 QDIHLALESD 1510 NSSSKSSCSS 1520 SWTSRSVAPG 1530 FQYHPNLPMH 1540 AVIMEKSNDH 1550 FIVKIRRATP 1560 STSSGLKQSM 1570 MPDELLTSLP 1580 RHGKEADEGP 1590 EKEYISCQNT 1600 VFKSVEELEN 1610 SNKNVDGSKS 1620 THEEQSSMIQ 1630 TQVPDIYEFL 1640 KDASDKMGHS 1650 DEVADECFKL 1660 HQVWETKVPE 1670 SIEELPSMEE 1680 ISHSVGEHLP 1690 NTYVDLTKDP 1700 VTETKNLGEF 1710 IEVTVLHIDQ 1720 LGCSGGNLNQ 1730 SAQILDNSLQ 1740 ADTVGAFIDL 1750 TQDASSEAKS 1760 EGNHPALAVE 1770 DLGCGVIQVD 1780 EDNCKEEKAQ 1790 VANRPLKCIV 1800 EETYIDLTTE 1810 SPSSCEVKKD 1820 ELKSEPGSNC 1830 DNSELPGTLH 1840 NSHKKRRNIS 1850 DLNHPHKKQR 1860 KETDLTNKEK 1870 TKKPTQDSCE 1880 NTEAHQKKAS 1890 KKKAPPVTKD 1900 PSSLKATPGI 1910 KDSSAALATS 1920 TSLSAKNVIK 1930 KKGEIIILWT 1940 RNDDREILLE 1950 CQKRGPSFKT 1960 FAYLAAKLDK 1970 NPNQVSERFQ 1980 QLMKLFEKSK CR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0016605	PML body
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
Molecular Function	GO:0005123	death receptor binding
Molecular Function	GO:0016505	peptidase activator activity involved in apoptotic process
Molecular Function	GO:0032184	SUMO polymer binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0097190	apoptotic signaling pathway
Biological Process	GO:0071260	cellular response to mechanical stimulus
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
Biological Process	GO:0036337	Fas signaling pathway
Biological Process	GO:0007165	signal transduction

Reference

PMID: N/A