Search Results

Overview

Uniprot IDQ9UKM9
Protein NameRNA-binding protein Raly
Gene NameRALY
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 QASNVTNKNDPKSIN
165 VKTNVPVKLFARSTA
179 AVTTSSAKIKLKSSE
183 SSAKIKLKSSELQAI
216 EQIAAEQKANPDGKK
34 NLNTALVKKSDVETI
35 LNTALVKKSDVETIF
4 ****MSLKLQASNVT
55 VAGCSVHKGYAFVQY
99 EPKPDRPKGLKRAAS

Function

RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072)

Protein Sequence

10 MSLKLQASNV 20 TNKNDPKSIN 30 SRVFIGNLNT 40 ALVKKSDVET 50 IFSKYGRVAG 60 CSVHKGYAFV 70 QYSNERHARA 80 AVLGENGRVL 90 AGQTLDINMA 100 GEPKPDRPKG 110 LKRAASAIYS 120 GYIFDYDYYR 130 DDFYDRLFDY 140 RGRLSPVPVP 150 RAVPVKRPRV 160 TVPLVRRVKT 170 NVPVKLFARS 180 TAVTTSSAKI 190 KLKSSELQAI 200 KTELTQIKSN 210 IDALLSRLEQ 220 IAAEQKANPD 230 GKKKGDGGGA 240 GGGGGGGGSG 250 GGGSGGGGGG 260 GSSRPPAPQE 270 NTTSEAGLPQ 280 GEARTRDDGD 290 EEGLLTHSEE 300 ELEHSQDTDA DDGALQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.