Search Results

Overview

Uniprot IDQ9UKN8
Protein NameGeneral transcription factor 3C polypeptide 4
Gene NameGTF3C4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
119 PLNSCLLKVGSKTEV
137 KEKFAASKDPTVSQT
156 RVFNPEGKALPPMRG
351 PVNLKAVKGYFTLRQ
633 TSSKQVVKQGLQERS
736 VLIGHISKKMNKQTF
737 LIGHISKKMNKQTFP
740 HISKKMNKQTFPEHC

Function

Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658)

Protein Sequence

10 MNTADQARVG 20 PADDGPAPSG 30 EEEGEGGGEA 40 GGKEPAADAA 50 PGPSAAFRLM 60 VTRREPAVKL 70 QYAVSGLEPL 80 AWSEDHRVSV 90 STARSIAVLE 100 LICDVHNPGQ 110 DLVIHRTSVP 120 APLNSCLLKV 130 GSKTEVAECK 140 EKFAASKDPT 150 VSQTFMLDRV 160 FNPEGKALPP 170 MRGFKYTSWS 180 PMGCDANGRC 190 LLAALTMDNR 200 LTIQANLNRL 210 QWVQLVDLTE 220 IYGERLYETS 230 YRLSKNEAPE 240 GNLGDFAEFQ 250 RRHSMQTPVR 260 MEWSGICTTQ 270 QVKHNNECRD 280 VGSVLLAVLF 290 ENGNIAVWQF 300 QLPFVGKESI 310 SSCNTIESGI 320 TSPSVLFWWE 330 YEHNNRKMSG 340 LIVGSAFGPI 350 KILPVNLKAV 360 KGYFTLRQPV 370 ILWKEMDQLP 380 VHSIKCVPLY 390 HPYQKCSCSL 400 VVAARGSYVF 410 WCLLLISKAG 420 LNVHNSHVTG 430 LHSLPIVSMT 440 ADKQNGTVYT 450 CSSDGKVRQL 460 IPIFTDVALK 470 FEHQLIKLSD 480 VFGSVRTHGI 490 AVSPCGAYLA 500 IITTEGMING 510 LHPVNKNYQV 520 QFVTLKTFEE 530 AAAQLLESSV 540 QNLFKQVDLI 550 DLVRWKILKD 560 KHIPQFLQEA 570 LEKKIESSGV 580 TYFWRFKLFL 590 LRILYQSMQK 600 TPSEALWKPT 610 HEDSKILLVD 620 SPGMGNADDE 630 QQEEGTSSKQ 640 VVKQGLQERS 650 KEGDVEEPTD 660 DSLPTTGDAG 670 GREPMEEKLL 680 EIQGKIEAVE 690 MHLTREHMKR 700 VLGEVYLHTW 710 ITENTSIPTR 720 GLCNFLMSDE 730 EYDDRTARVL 740 IGHISKKMNK 750 QTFPEHCSLC 760 KEILPFTDRK 770 QAVCSNGHIW 780 LRCFLTYQSC 790 QSLIYRRCLL 800 HDSIARHPAP 810 EDPDWIKRLL 820 QSPCPFCDSP VF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000127 transcription factor TFIIIC complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0036408 histone H3K14 acetyltransferase activity
Molecular Function GO:0000995 RNA polymerase III general transcription initiation factor activity
Biological Process GO:0042791 5S class rRNA transcription by RNA polymerase III
Biological Process GO:0006383 transcription by RNA polymerase III
Biological Process GO:0006384 transcription initiation at RNA polymerase III promoter
Biological Process GO:0042797 tRNA transcription by RNA polymerase III

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.