Search Results
Overview
| Uniprot ID | Q9UKS6 |
|---|---|
| Protein Name | Protein kinase C and casein kinase substrate in neurons protein 3 |
| Gene Name | PACSIN3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 203 | AKEAEKTKAQYEQTL |
Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity)
Protein Sequence
10
MAPEEDAGGE
20
ALGGSFWEAG
30
NYRRTVQRVE
40
DGHRLCGDLV
50
SCFQERARIE
60
KAYAQQLADW
70
ARKWRGTVEK
80
GPQYGTLEKA
90
WHAFFTAAER
100
LSALHLEVRE
110
KLQGQDSERV
120
RAWQRGAFHR
130
PVLGGFRESR
140
AAEDGFRKAQ
150
KPWLKRLKEV
160
EASKKSYHAA
170
RKDEKTAQTR
180
ESHAKADSAV
190
SQEQLRKLQE
200
RVERCAKEAE
210
KTKAQYEQTL
220
AELHRYTPRY
230
MEDMEQAFET
240
CQAAERQRLL
250
FFKDMLLTLH
260
QHLDLSSSEK
270
FHELHRDLHQ
280
GIEAASDEED
290
LRWWRSTHGP
300
GMAMNWPQFE
310
EWSLDTQRTI
320
SRKEKGGRSP
330
DEVTLTSIVP
340
TRDGTAPPPQ
350
SPGSPGTGQD
360
EEWSDEESPR
370
KAATGVRVRA
380
LYDYAGQEAD
390
ELSFRAGEEL
400
LKMSEEDEQG
410
WCQGQLQSGR
420
IGLYPANYVE
CVGA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0051926 | negative regulation of calcium ion transport |
| Biological Process | GO:0045806 | negative regulation of endocytosis |
| Biological Process | GO:0097320 | plasma membrane tubulation |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| Biological Process | GO:0030100 | regulation of endocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.