Overview
| Uniprot ID | Q9UKT5 |
|---|
| Protein Name | F-box only protein 4 |
|---|
| Gene Name | FBXO4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 257 |
EHTSAVNKMFSRHNE |
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10531035, PubMed:18598945, PubMed:20181953, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:18598945). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (By similarity). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209)
Protein Sequence
10
MAGSEPRSGT
20
NSPPPPFSDW
30
GRLEAAILSG
40
WKTFWQSVSK
50
ERVARTTSRE
60
EVDEAASTLT
70
RLPIDVQLYI
80
LSFLSPHDLC
90
QLGSTNHYWN
100
ETVRDPILWR
110
YFLLRDLPSW
120
SSVDWKSLPD
130
LEILKKPISE
140
VTDGAFFDYM
150
AVYRMCCPYT
160
RRASKSSRPM
170
YGAVTSFLHS
180
LIIQNEPRFA
190
MFGPGLEELN
200
TSLVLSLMSS
210
EELCPTAGLP
220
QRQIDGIGSG
230
VNFQLNNQHK
240
FNILILYSTT
250
RKERDRAREE
260
HTSAVNKMFS
270
RHNEGDDQQG
280
SRYSVIPQIQ
290
KVCEVVDGFI
300
YVANAEAHKR
310
HEWQDEFSHI
320
MAMTDPAFGS
330
SGRPLLVLSC
340
ISQGDVKRMP
350
CFYLAHELHL
360
NLLNHPWLVQ
370
DTEAETLTGF
380
LNGIEWILEE
VESKRAR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0019005 |
SCF ubiquitin ligase complex |
| Cellular Component |
GO:0000151 |
ubiquitin ligase complex |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Molecular Function |
GO:1990756 |
ubiquitin-like ligase-substrate adaptor activity |
| Molecular Function |
GO:0004842 |
ubiquitin-protein transferase activity |
| Biological Process |
GO:0031398 |
positive regulation of protein ubiquitination |
| Biological Process |
GO:0032212 |
positive regulation of telomere maintenance via telomerase |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:2000001 |
regulation of DNA damage checkpoint |
| Biological Process |
GO:0031647 |
regulation of protein stability |
| Biological Process |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0000723 |
telomere maintenance |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.