Overview
| Uniprot ID | Q9UKT6 |
|---|
| Protein Name | Putative F-box/LRR-repeat protein 21 |
|---|
| Gene Name | FBXL21P |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
VQLSGAAKQPKVGFY |
Function
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity)
Protein Sequence
10
MKRNSLSVEN
20
KIVQLSGAAK
30
QPKVGFYSSL
40
NQTHTHTVLL
50
DWGSLPHHVV
60
LQIFQYLPLL
70
DRACASSVCR
80
RWNEVFHISD
90
LWRKFEFELN
100
QSATSSFKST
110
HPDLIQQIIK
120
KHFAHLQYVS
130
FKVDSSAESA
140
EAACDILSQL
150
VNCSIQTLGL
160
ISTAKPSFMN
170
VSESHFVSAL
180
TVVFINSKSL
190
SSIKIEDTPV
200
DDPSLKILVA
210
NNSDTLRLPK
220
MSSCPHVSSD
230
GILCVADRCQ
240
GLRELALNYY
250
ILTDELFLAL
260
SSETHVNLEH
270
LRIDVVSENP
280
GQIKFHAVKK
290
HSWDALIKHS
300
PRVNVVMHFF
310
LYEEEFETFF
320
KEETPVTHLY
330
FGRSVSKVVL
340
GRVGLNCPRL
350
IELVVCANDL
360
QPLDNELICI
370
AEHCTNLTAL
380
GLSKCEVSCS
390
AFIRFVRLCE
400
RRLTQLSVME
410
EVLIPDEDYS
420
LDEIHTEVSK
430
YLGRVWFPDV
MPLW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019005 |
SCF ubiquitin ligase complex |
| Cellular Component |
GO:0000151 |
ubiquitin ligase complex |
| Molecular Function |
GO:0004842 |
ubiquitin-protein transferase activity |
| Biological Process |
GO:0043153 |
entrainment of circadian clock by photoperiod |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0042752 |
regulation of circadian rhythm |
| Biological Process |
GO:0048511 |
rhythmic process |
| Biological Process |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.