Search Results
Overview
| Uniprot ID | Q9UKU0 |
|---|---|
| Protein Name | Long-chain-fatty-acid--CoA ligase 6 |
| Gene Name | ACSL6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 561 | DRKKHIFKLAQGEYV |
| 675 | GLLTPTLKAKRPELR |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid
Protein Sequence
10
MQTQEILRIL
20
RLPELGDLGQ
30
FFRSLSATTL
40
VSMGALAAIL
50
AYWFTHRPKA
60
LQPPCNLLMQ
70
SEEVEDSGGA
80
RRSVIGSGPQ
90
LLTHYYDDAR
100
TMYQVFRRGL
110
SISGNGPCLG
120
FRKPKQPYQW
130
LSYQEVADRA
140
EFLGSGLLQH
150
NCKACTDQFI
160
GVFAQNRPEW
170
IIVELACYTY
180
SMVVVPLYDT
190
LGPGAIRYII
200
NTADISTVIV
210
DKPQKAVLLL
220
EHVERKETPG
230
LKLIILMDPF
240
EEALKERGQK
250
CGVVIKSMQA
260
VEDCGQENHQ
270
APVPPQPDDL
280
SIVCFTSGTT
290
GNPKGAMLTH
300
GNVVADFSGF
310
LKVTEKVIFP
320
RQDDVLISFL
330
PLAHMFERVI
340
QSVVYCHGGR
350
VGFFQGDIRL
360
LSDDMKALCP
370
TIFPVVPRLL
380
NRMYDKIFSQ
390
ANTPLKRWLL
400
EFAAKRKQAE
410
VRSGIIRNDS
420
IWDELFFNKI
430
QASLGGCVRM
440
IVTGAAPASP
450
TVLGFLRAAL
460
GCQVYEGYGQ
470
TECTAGCTFT
480
TPGDWTSGHV
490
GAPLPCNHIK
500
LVDVEELNYW
510
ACKGEGEICV
520
RGPNVFKGYL
530
KDPDRTKEAL
540
DSDGWLHTGD
550
IGKWLPAGTL
560
KIIDRKKHIF
570
KLAQGEYVAP
580
EKIENIYIRS
590
QPVAQIYVHG
600
DSLKAFLVGI
610
VVPDPEVMPS
620
WAQKRGIEGT
630
YADLCTNKDL
640
KKAILEDMVR
650
LGKESGLHSF
660
EQVKAIHIHS
670
DMFSVQNGLL
680
TPTLKAKRPE
690
LREYFKKQIE
ELYSISM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.