Search Results
Overview
| Uniprot ID | Q9UKU7 |
|---|---|
| Protein Name | Isobutyryl-CoA dehydrogenase, mitochondrial |
| Gene Name | ACAD8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 213 | RTGGPGPKGISCIVV |
| 345 | VALQEERKDAVALCS |
Function
Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760). To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA (PubMed:11013134, PubMed:12359132)
Protein Sequence
10
MLWSGCRRFG
20
ARLGCLPGGL
30
RVLVQTGHRS
40
LTSCIDPSMG
50
LNEEQKEFQK
60
VAFDFAAREM
70
APNMAEWDQK
80
ELFPVDVMRK
90
AAQLGFGGVY
100
IQTDVGGSGL
110
SRLDTSVIFE
120
ALATGCTSTT
130
AYISIHNMCA
140
WMIDSFGNEE
150
QRHKFCPPLC
160
TMEKFASYCL
170
TEPGSGSDAA
180
SLLTSAKKQG
190
DHYILNGSKA
200
FISGAGESDI
210
YVVMCRTGGP
220
GPKGISCIVV
230
EKGTPGLSFG
240
KKEKKVGWNS
250
QPTRAVIFED
260
CAVPVANRIG
270
SEGQGFLIAV
280
RGLNGGRINI
290
ASCSLGAAHA
300
SVILTRDHLN
310
VRKQFGEPLA
320
SNQYLQFTLA
330
DMATRLVAAR
340
LMVRNAAVAL
350
QEERKDAVAL
360
CSMAKLFATD
370
ECFAICNQAL
380
QMHGGYGYLK
390
DYAVQQYVRD
400
SRVHQILEGS
410
NEVMRILISR
SLLQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003995 | acyl-CoA dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0003853 | short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006574 | L-valine catabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.