Search Results

Overview

Uniprot IDQ9UKV3
Protein NameApoptotic chromatin condensation inducer in the nucleus
Gene NameACIN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 SALVKRLKGALMLEN
143 FIKQYLEKQQELLRQ
238 VRQARAAKLSEGSQP
302 SREAPILKEFKEEGE
349 RSQEEARKSHLARQQ
398 RLTEDRKKASLVALP
506 SVLPLVQKSTLADYS
516 LADYSAQKDLEPESD
532 SAQPLPLKIEELALA
548 GITEECLKQPSLEQK
81 ALRVTDLKAALEQRG
818 KKESSLPKSFKRKIS
823 LPKSFKRKISVVSAT
831 ISVVSATKGVPAGNS
860 ASTATTQKKPSISIT
861 STATTQKKPSISITT
970 PAEHEVKKVTLGDTL
986 RRSISQQKSGVSITI

Function

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells

Protein Sequence

10 MWRRKHPRTS 20 GGTRGVLSGN 30 RGVEYGSGRG 40 HLGTFEGRWR 50 KLPKMPEAVG 60 TDPSTSRKMA 70 ELEEVTLDGK 80 PLQALRVTDL 90 KAALEQRGLA 100 KSGQKSALVK 110 RLKGALMLEN 120 LQKHSTPHAA 130 FQPNSQIGEE 140 MSQNSFIKQY 150 LEKQQELLRQ 160 RLEREAREAA 170 ELEEASAESE 180 DEMIHPEGVA 190 SLLPPDFQSS 200 LERPELELSR 210 HSPRKSSSIS 220 EEKGDSDDEK 230 PRKGERRSSR 240 VRQARAAKLS 250 EGSQPAEEEE 260 DQETPSRNLR 270 VRADRNLKTE 280 EEEEEEEEEE 290 EDDEEEEGDD 300 EGQKSREAPI 310 LKEFKEEGEE 320 IPRVKPEEMM 330 DERPKTRSQE 340 QEVLERGGRF 350 TRSQEEARKS 360 HLARQQQEKE 370 MKTTSPLEEE 380 EREIKSSQGL 390 KEKSKSPSPP 400 RLTEDRKKAS 410 LVALPEQTAS 420 EEETPPPLLT 430 KEASSPPPHP 440 QLHSEEEIEP 450 MEGPAPAVLI 460 QLSPPNTDAD 470 TRELLVSQHT 480 VQLVGGLSPL 490 SSPSDTKAES 500 PAEKVPEESV 510 LPLVQKSTLA 520 DYSAQKDLEP 530 ESDRSAQPLP 540 LKIEELALAK 550 GITEECLKQP 560 SLEQKEGRRA 570 SHTLLPSHRL 580 KQSADSSSSR 590 SSSSSSSSSR 600 SRSRSPDSSG 610 SRSHSPLRSK 620 QRDVAQARTH 630 ANPRGRPKMG 640 SRSTSESRSR 650 SRSRSRSASS 660 NSRKSLSPGV 670 SRDSSTSYTE 680 TKDPSSGQEV 690 ATPPVPQLQV 700 CEPKERTSTS 710 SSSVQARRLS 720 QPESAEKHVT 730 QRLQPERGSP 740 KKCEAEEAEP 750 PAATQPQTSE 760 TQTSHLPESE 770 RIHHTVEEKE 780 EVTMDTSENR 790 PENDVPEPPM 800 PIADQVSNDD 810 RPEGSVEDEE 820 KKESSLPKSF 830 KRKISVVSAT 840 KGVPAGNSDT 850 EGGQPGRKRR 860 WGASTATTQK 870 KPSISITTES 880 LKSLIPDIKP 890 LAGQEAVVDL 900 HADDSRISED 910 ETERNGDDGT 920 HDKGLKICRT 930 VTQVVPAEGQ 940 ENGQREEEEE 950 EKEPEAEPPV 960 PPQVSVEVAL 970 PPPAEHEVKK 980 VTLGDTLTRR 990 SISQQKSGVS 1000 ITIDDPVRTA 1010 QVPSPPRGKI 1020 SNIVHISNLV 1030 RPFTLGQLKE 1040 LLGRTGTLVE 1050 EAFWIDKIKS 1060 HCFVTYSTVE 1070 EAVATRTALH 1080 GVKWPQSNPK 1090 FLCADYAEQD 1100 ELDYHRGLLV 1110 DRPSETKTEE 1120 QGIPRPLHPP 1130 PPPPVQPPQH 1140 PRAEQREQER 1150 AVREQWAERE 1160 REMERRERTR 1170 SEREWDRDKV 1180 REGPRSRSRS 1190 RDRRRKERAK 1200 SKEKKSEKKE 1210 KAQEEPPAKL 1220 LDDLFRKTKA 1230 APCIYWLPLT 1240 DSQIVQKEAE 1250 RAERAKEREK 1260 RRKEQEEEEQ 1270 KEREKEAERE 1280 RNRQLEREKR 1290 REHSRERDRE 1300 RERERERDRG 1310 DRDRDRERDR 1320 ERGRERDRRD 1330 TKRHSRSRSR 1340 STPVRDRGGR R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0061574 ASAP complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030263 apoptotic chromosome condensation
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0048025 negative regulation of mRNA splicing, via spliceosome
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045657 positive regulation of monocyte differentiation
Biological Process GO:0050684 regulation of mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.