Search Results

Overview

Uniprot IDQ9UKX2
Protein NameMyosin-2
Gene NameMYH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1762 RNAEEKAKKAITDAA
1885 QAKVKSYKRQAEEAE
1901 QSNTNLAKFRKLQHE
568 GKSANFQKPKVVKGK
871 KIKDELAKSEAKRKE

Function

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction

Protein Sequence

10 MSSDSELAVF 20 GEAAPFLRKS 30 ERERIEAQNR 40 PFDAKTSVFV 50 AEPKESFVKG 60 TIQSREGGKV 70 TVKTEGGATL 80 TVKDDQVFPM 90 NPPKYDKIED 100 MAMMTHLHEP 110 AVLYNLKERY 120 AAWMIYTYSG 130 LFCVTVNPYK 140 WLPVYKPEVV 150 TAYRGKKRQE 160 APPHIFSISD 170 NAYQFMLTDR 180 ENQSILITGE 190 SGAGKTVNTK 200 RVIQYFATIA 210 VTGEKKKEEI 220 TSGKIQGTLE 230 DQIISANPLL 240 EAFGNAKTVR 250 NDNSSRFGKF 260 IRIHFGTTGK 270 LASADIETYL 280 LEKSRVVFQL 290 KAERSYHIFY 300 QITSNKKPEL 310 IEMLLITTNP 320 YDYPFVSQGE 330 ISVASIDDQE 340 ELMATDSAID 350 ILGFTNEEKV 360 SIYKLTGAVM 370 HYGNLKFKQK 380 QREEQAEPDG 390 TEVADKAAYL 400 QSLNSADLLK 410 ALCYPRVKVG 420 NEYVTKGQTV 430 EQVSNAVGAL 440 AKAVYEKMFL 450 WMVARINQQL 460 DTKQPRQYFI 470 GVLDIAGFEI 480 FDFNSLEQLC 490 INFTNEKLQQ 500 FFNHHMFVLE 510 QEEYKKEGIE 520 WTFIDFGMDL 530 AACIELIEKP 540 MGIFSILEEE 550 CMFPKATDTS 560 FKNKLYDQHL 570 GKSANFQKPK 580 VVKGKAEAHF 590 ALIHYAGVVD 600 YNITGWLEKN 610 KDPLNETVVG 620 LYQKSAMKTL 630 AQLFSGAQTA 640 EGEGAGGGAK 650 KGGKKKGSSF 660 QTVSALFREN 670 LNKLMTNLRS 680 THPHFVRCII 690 PNETKTPGAM 700 EHELVLHQLR 710 CNGVLEGIRI 720 CRKGFPSRIL 730 YADFKQRYKV 740 LNASAIPEGQ 750 FIDSKKASEK 760 LLASIDIDHT 770 QYKFGHTKVF 780 FKAGLLGLLE 790 EMRDDKLAQL 800 ITRTQARCRG 810 FLARVEYQRM 820 VERREAIFCI 830 QYNIRSFMNV 840 KHWPWMKLFF 850 KIKPLLKSAE 860 TEKEMATMKE 870 EFQKIKDELA 880 KSEAKRKELE 890 EKMVTLLKEK 900 NDLQLQVQAE 910 AEGLADAEER 920 CDQLIKTKIQ 930 LEAKIKEVTE 940 RAEDEEEINA 950 ELTAKKRKLE 960 DECSELKKDI 970 DDLELTLAKV 980 EKEKHATENK 990 VKNLTEEMAG 1000 LDETIAKLTK 1010 EKKALQEAHQ 1020 QTLDDLQAEE 1030 DKVNTLTKAK 1040 IKLEQQVDDL 1050 EGSLEQEKKL 1060 RMDLERAKRK 1070 LEGDLKLAQE 1080 SIMDIENEKQ 1090 QLDEKLKKKE 1100 FEISNLQSKI 1110 EDEQALGIQL 1120 QKKIKELQAR 1130 IEELEEEIEA 1140 ERASRAKAEK 1150 QRSDLSRELE 1160 EISERLEEAG 1170 GATSAQIEMN 1180 KKREAEFQKM 1190 RRDLEEATLQ 1200 HEATAATLRK 1210 KHADSVAELG 1220 EQIDNLQRVK 1230 QKLEKEKSEM 1240 KMEIDDLASN 1250 VETVSKAKGN 1260 LEKMCRTLED 1270 QLSELKSKEE 1280 EQQRLINDLT 1290 AQRGRLQTES 1300 GEFSRQLDEK 1310 EALVSQLSRG 1320 KQAFTQQIEE 1330 LKRQLEEEIK 1340 AKNALAHALQ 1350 SSRHDCDLLR 1360 EQYEEEQESK 1370 AELQRALSKA 1380 NTEVAQWRTK 1390 YETDAIQRTE 1400 ELEEAKKKLA 1410 QRLQAAEEHV 1420 EAVNAKCASL 1430 EKTKQRLQNE 1440 VEDLMLDVER 1450 TNAACAALDK 1460 KQRNFDKILA 1470 EWKQKCEETH 1480 AELEASQKEA 1490 RSLGTELFKI 1500 KNAYEESLDQ 1510 LETLKRENKN 1520 LQQEISDLTE 1530 QIAEGGKRIH 1540 ELEKIKKQVE 1550 QEKCELQAAL 1560 EEAEASLEHE 1570 EGKILRIQLE 1580 LNQVKSEVDR 1590 KIAEKDEEID 1600 QLKRNHIRIV 1610 ESMQSTLDAE 1620 IRSRNDAIRL 1630 KKKMEGDLNE 1640 MEIQLNHANR 1650 MAAEALRNYR 1660 NTQGILKDTQ 1670 IHLDDALRSQ 1680 EDLKEQLAMV 1690 ERRANLLQAE 1700 IEELRATLEQ 1710 TERSRKIAEQ 1720 ELLDASERVQ 1730 LLHTQNTSLI 1740 NTKKKLETDI 1750 SQMQGEMEDI 1760 LQEARNAEEK 1770 AKKAITDAAM 1780 MAEELKKEQD 1790 TSAHLERMKK 1800 NMEQTVKDLQ 1810 LRLDEAEQLA 1820 LKGGKKQIQK 1830 LEARVRELEG 1840 EVESEQKRNA 1850 EAVKGLRKHE 1860 RRVKELTYQT 1870 EEDRKNILRL 1880 QDLVDKLQAK 1890 VKSYKRQAEE 1900 AEEQSNTNLA 1910 KFRKLQHELE 1920 EAEERADIAE 1930 SQVNKLRVKS 1940 REVHTKVISE E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005859 muscle myosin complex
Cellular Component GO:0030016 myofibril
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0030017 sarcomere
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.