Search Results

Overview

Uniprot ID	Q9UKX7
Protein Name	Nuclear pore complex protein Nup50
Gene Name	NUP50
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
149	SSGLASSKACVGNAY
59	SDTGGAFKGFKGLVV
62	GGAFKGFKGLVVPSG

Function

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity)

Protein Sequence

10 MAKRNAEKEL 20 TDRNWDQEDE 30 AEEVGTFSMA 40 SEEVLKNRAI 50 KKAKRRNVGF 60 ESDTGGAFKG 70 FKGLVVPSGG 80 GRFSGFGSGA 90 GGKPLEGLSN 100 GNNITSAPPF 110 ASAKAAADPK 120 VAFGSLAANG 130 PTTLVDKVSN 140 PKTNGDSQQP 150 SSSGLASSKA 160 CVGNAYHKQL 170 AALNCSVRDW 180 IVKHVNTNPL 190 CDLTPIFKDY 200 EKYLANIEQQ 210 HGNSGRNSES 220 ESNKVAAETQ 230 SPSLFGSTKL 240 QQESTFLFHG 250 NKTEDTPDKK 260 MEVASEKKTD 270 PSSLGATSAS 280 FNFGKKVDSS 290 VLGSLSSVPL 300 TGFSFSPGNS 310 SLFGKDTTQS 320 KPVSSPFPTK 330 PLEGQAEGDS 340 GECKGGDEEE 350 NDEPPKVVVT 360 EVKEEDAFYS 370 KKCKLFYKKD 380 NEFKEKGIGT 390 LHLKPTANQK 400 TQLLVRADTN 410 LGNILLNVLI 420 PPNMPCTRTG 430 KNNVLIVCVP 440 NPPIDEKNAT 450 MPVTMLIRVK 460 TSEDADELHK ILLEKKDA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0005654	nucleoplasm
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0006606	protein import into nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.