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Overview

Uniprot IDQ9UKY1
Protein NameZinc fingers and homeoboxes protein 1
Gene NameZHX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
180 SSGISISKTPIMKMM
777 DRGPSLIKFKTGTAI

Function

Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins

Protein Sequence

10 MASRRKSTTP 20 CMVLASEQDP 30 DLELISDLDE 40 GPPVLTPVEN 50 TRAESISSDE 60 EVHESVDSDN 70 QQNKKVEGGY 80 ECKYCTFQTP 90 DLNMFTFHVD 100 SEHPNVVLNS 110 SYVCVECNFL 120 TKRYDALSEH 130 NLKYHPGEEN 140 FKLTMVKRNN 150 QTIFEQTIND 160 LTFDGSFVKE 170 ENAEQAESTE 180 VSSSGISISK 190 TPIMKMMKNK 200 VENKRIAVHH 210 NSVEDVPEEK 220 ENEIKPDREE 230 IVENPSSSAS 240 ESNTSTSIVN 250 RIHPSTASTV 260 VTPAAVLPGL 270 AQVITAVSAQ 280 QNSNLIPKVL 290 IPVNSIPTYN 300 AALDNNPLLL 310 NTYNKFPYPT 320 MSEITVLSAQ 330 AKYTEEQIKI 340 WFSAQRLKHG 350 VSWTPEEVEE 360 ARRKQFNGTV 370 HTVPQTITVI 380 PTHISTGSNG 390 LPSILQTCQI 400 VGQPGLVLTQ 410 VAGTNTLPVT 420 APIALTVAGV 430 PSQNNIQKSQ 440 VPAAQPTAET 450 KPATAAVPTS 460 QSVKHETALV 470 NPDSFGIRAK 480 KTKEQLAELK 490 VSYLKNQFPH 500 DSEIIRLMKI 510 TGLTKGEIKK 520 WFSDTRYNQR 530 NSKSNQCLHL 540 NNDSSTTIII 550 DSSDETTESP 560 TVGTAQPKQS 570 WNPFPDFTPQ 580 KFKEKTAEQL 590 RVLQASFLNS 600 SVLTDEELNR 610 LRAQTKLTRR 620 EIDAWFTEKK 630 KSKALKEEKM 640 EIDESNAGSS 650 KEEAGETSPA 660 DESGAPKSGS 670 TGKICKKTPE 680 QLHMLKSAFV 690 RTQWPSPEEY 700 DKLAKESGLA 710 RTDIVSWFGD 720 TRYAWKNGNL 730 KWYYYYQSAN 740 SSSMNGLSSL 750 RKRGRGRPKG 760 RGRGRPRGRP 770 RGSKRINNWD 780 RGPSLIKFKT 790 GTAILKDYYL 800 KHKFLNEQDL 810 DELVNKSHMG 820 YEQVREWFAE 830 RQRRSELGIE 840 LFEENEEEDE 850 VIDDQEEDEE 860 ETDDSDTWEP 870 PRHVKRKLSK SDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.