Overview
| Uniprot ID | Q9UL03 |
|---|
| Protein Name | Integrator complex subunit 6 |
|---|
| Gene Name | INTS6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 795 |
IPASSLNKGKKLMHC |
Function
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144)
Protein Sequence
10
MPILLFLIDT
20
SASMNQRSHL
30
GTTYLDTAKG
40
AVETFMKLRA
50
RDPASRGDRY
60
MLVTFEEPPY
70
AIKAGWKENH
80
ATFMNELKNL
90
QAEGLTTLGQ
100
SLRTAFDLLN
110
LNRLVTGIDN
120
YGQGRNPFFL
130
EPAIIITITD
140
GSKLTTTSGV
150
QDELHLPLNS
160
PLPGSELTKE
170
PFRWDQRLFA
180
LVLRLPGTMS
190
VESEQLTGVP
200
LDDSAITPMC
210
EVTGGRSYSV
220
CSPRMLNQCL
230
ESLVQKVQSG
240
VVINFEKAGP
250
DPSPVEDGQP
260
DISRPFGSQP
270
WHSCHKLIYV
280
RPNPKTGVPI
290
GHWPVPESFW
300
PDQNSPTLPP
310
RTSHPVVKFS
320
CTDCEPMVID
330
KLPFDKYELE
340
PSPLTQFILE
350
RKSPQTCWQV
360
YVSNSAKYSE
370
LGHPFGYLKA
380
STALNCVNLF
390
VMPYNYPVLL
400
PLLDDLFKVH
410
KAKPTLKWRQ
420
SFESYLKTMP
430
PYYLGPLKKA
440
VRMMGAPNLI
450
ADSMEYGLSY
460
SVISYLKKLS
470
QQAKIESDRV
480
IGSVGKKVVQ
490
ETGIKVRSRS
500
HGLSMAYRKD
510
FQQLLQGISE
520
DVPHRLLDLN
530
MKEYTGFQVA
540
LLNKDLKPQT
550
FRNAYDIPRR
560
NLLDHLTRMR
570
SNLLKSTRRF
580
LKGQDEDQVH
590
SVPIAQMGNY
600
QEYLKQVPSP
610
LRELDPDQPR
620
RLHTFGNPFK
630
LDKKGMMIDE
640
ADEFVAGPQN
650
KHKRPGEPNM
660
QGIPKRRRCM
670
SPLLRGRQQN
680
PVVNNHIGGK
690
GPPAPTTQAQ
700
PDLIKPLPLH
710
KISETTNDSI
720
IHDVVENHVA
730
DQLSSDITPN
740
AMDTEFSASS
750
PASLLERPTN
760
HMEALGHDHL
770
GTNDLTVGGF
780
LENHEEPRDK
790
EQCAEENIPA
800
SSLNKGKKLM
810
HCRSHEEVNT
820
ELKAQIMKEI
830
RKPGRKYERI
840
FTLLKHVQGS
850
LQTRLIFLQN
860
VIKEASRFKK
870
RMLIEQLENF
880
LDEIHRRANQ
INHINSN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0160232 |
INTAC complex |
| Cellular Component |
GO:0032039 |
integrator complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0004888 |
transmembrane signaling receptor activity |
| Biological Process |
GO:0071168 |
protein localization to chromatin |
| Biological Process |
GO:0034243 |
regulation of transcription elongation by RNA polymerase II |
| Biological Process |
GO:0160240 |
RNA polymerase II transcription initiation surveillance |
| Biological Process |
GO:0034472 |
snRNA 3'-end processing |
| Biological Process |
GO:0016180 |
snRNA processing |
Reference
PMID: N/A