Search Results

Overview

Uniprot IDQ9UL12
Protein NameSarcosine dehydrogenase, mitochondrial
Gene NameSARDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
173 KRLMSLGKAYGVESH
373 NRVPVLEKTGIKSTV
47 VPYQRTLKEGQGTSV
559 PHHDTIKKECLACRG
757 AVMAAGAKHGLINAG
775 IDSLSIEKGYRHWHA
912 SPFDPNNKRVKGIY*

Function

Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine

Protein Sequence

10 MASLSRALRV 20 AAAHPRQSPT 30 RGMGPCNLSS 40 AAGPTAEKSV 50 PYQRTLKEGQ 60 GTSVVAQGPS 70 RPLPSTANVV 80 VIGGGSLGCQ 90 TLYHLAKLGM 100 SGAVLLERER 110 LTSGTTWHTA 120 GLLWQLRPSD 130 VEVELLAHTR 140 RVVSRELEEE 150 TGLHTGWIQN 160 GGLFIASNRQ 170 RLDEYKRLMS 180 LGKAYGVESH 190 VLSPAETKTL 200 YPLMNVDDLY 210 GTLYVPHDGT 220 MDPAGTCTTL 230 ARAASARGAQ 240 VIENCPVTGI 250 RVWTDDFGVR 260 RVAGVETQHG 270 SIQTPCVVNC 280 AGVWASAVGR 290 MAGVKVPLVA 300 MHHAYVVTER 310 IEGIQNMPNV 320 RDHDASVYLR 330 LQGDALSVGG 340 YEANPIFWEE 350 VSDKFAFGLF 360 DLDWEVFTQH 370 IEGAINRVPV 380 LEKTGIKSTV 390 CGPESFTPDH 400 KPLMGEAPEL 410 RGFFLGCGFN 420 SAGMMLGGGC 430 GQELAHWIIH 440 GRPEKDMHGY 450 DIRRFHHSLT 460 DHPRWIRERS 470 HESYAKNYSV 480 VFPHDEPLAG 490 RNMRRDPLHE 500 ELLGQGCVFQ 510 ERHGWERPGW 520 FHPRGPAPVL 530 EYDYYGAYGS 540 RAHEDYAYRR 550 LLADEYTFAF 560 PPHHDTIKKE 570 CLACRGAAAV 580 FDMSYFGKFY 590 LVGLDARKAA 600 DWLFSADVSR 610 PPGSTVYTCM 620 LNHRGGTESD 630 LTVSRLAPSH 640 QASPLAPAFE 650 GDGYYLAMGG 660 AVAQHNWSHI 670 TTVLQDQKSQ 680 CQLIDSSEDL 690 GMISIQGPAS 700 RAILQEVLDA 710 DLSNEAFPFS 720 THKLLRAAGH 730 LVRAMRLSFV 740 GELGWELHIP 750 KASCVPVYRA 760 VMAAGAKHGL 770 INAGYRAIDS 780 LSIEKGYRHW 790 HADLRPDDSP 800 LEAGLAFTCK 810 LKSPVPFLGR 820 EALEQQRAAG 830 LRRRLVCFTM 840 EDKVPMFGLE 850 AIWRNGQVVG 860 HVRRADFGFA 870 IDKTIAYGYI 880 HDPSGGPVSL 890 DFVKSGDYAL 900 ERMGVTYGAQ 910 AHLKSPFDPN NKRVKGIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0008480 sarcosine dehydrogenase activity
Biological Process GO:1901053 sarcosine catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.