Search Results
Overview
| Uniprot ID | Q9UL16 |
|---|---|
| Protein Name | Cilia- and flagella-associated protein 45 |
| Gene Name | CFAP45 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 413 | EKENARKKMETEAEL |
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725)
Protein Sequence
10
MPLSTAGILS
20
SSSAASNRSR
30
NKARYRTKAV
40
SSEVDESLFG
50
DIKSPAQGQS
60
DSPIVLLRDK
70
HTLQKTLTAL
80
GLDRKPETIQ
90
LITRDMVREL
100
IVPTEDPSGE
110
SLIISPEEFE
120
RIKWASHVLT
130
REELEARDQA
140
FKKEKEATMD
150
AVMTRKKIMK
160
QKEMVWNNNK
170
KLSDLEEVAK
180
ERAQNLLQRA
190
NKLRMEQEEE
200
LKDMSKIILN
210
AKCHAIRDAQ
220
ILEKQQIQKE
230
LDTEEKRLDQ
240
MMEVERQKSI
250
QRQEELERKR
260
REERIRGRRQ
270
IVEQMEKNQE
280
ERSLLAEQRE
290
QEKEQMLEYM
300
EQLQEEDLKD
310
MERRQQQKLK
320
MQAEIKRIND
330
ENQKQKAELL
340
AQEKLADQMV
350
MEFTKKKMAR
360
EAEFEAEQER
370
IRREKEKEIA
380
RLRAMQEKAQ
390
DYQAEQDALR
400
AKRNQEVADR
410
EWRRKEKENA
420
RKKMETEAEL
430
RKSRLEQVAF
440
KEHALAVQVQ
450
RDRDEFERIL
460
RAQREQIEKE
470
RLEEEKKATG
480
RLQHANELRR
490
QVRENQQKEV
500
QNRIATFEEG
510
RRLKEEAQKR
520
RERIDEIKRK
530
KLEELRATGL
540
PEKYCIEAER
550
KANILPATSV
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097728 | 9+0 motile cilium |
| Cellular Component | GO:0097729 | 9+2 motile cilium |
| Cellular Component | GO:0160112 | axonemal B tubule inner sheath |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097229 | sperm end piece |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0016208 | AMP binding |
| Biological Process | GO:0061966 | establishment of left/right asymmetry |
| Biological Process | GO:0030317 | flagellated sperm motility |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.