Search Results

Overview

Uniprot IDQ9UL46
Protein NameProteasome activator complex subunit 2
Gene NamePSME2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
15 RLSGEARKQVEVFRQ
156 RVNAVKTKVEAFQTT
166 AFQTTISKYFSERGD
180 DAVAKASKETHVMDY

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

Protein Sequence

10 MAKPCGVRLS 20 GEARKQVEVF 30 RQNLFQEAEE 40 FLYRFLPQKI 50 IYLNQLLQED 60 SLNVADLTSL 70 RAPLDIPIPD 80 PPPKDDEMET 90 DKQEKKEVHK 100 CGFLPGNEKV 110 LSLLALVKPE 120 VWTLKEKCIL 130 VITWIQHLIP 140 KIEDGNDFGV 150 AIQEKVLERV 160 NAVKTKVEAF 170 QTTISKYFSE 180 RGDAVAKASK 190 ETHVMDYRAL 200 VHERDEAAYG 210 ELRAMVLDLR 220 AFYAELYHII 230 SSNLEKIVNP KGEEKPSMY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0008537 proteasome activator complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0034515 proteasome storage granule
Molecular Function GO:0061133 endopeptidase activator activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.