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Overview

Uniprot ID	Q9UL54
Protein Name	Serine/threonine-protein kinase TAO2
Gene Name	TAOK2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
11	GGRAGSLKDPDVAEL

Function

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation

Protein Sequence

10 MPAGGRAGSL 20 KDPDVAELFF 30 KDDPEKLFSD 40 LREIGHGSFG 50 AVYFARDVRN 60 SEVVAIKKMS 70 YSGKQSNEKW 80 QDIIKEVRFL 90 QKLRHPNTIQ 100 YRGCYLREHT 110 AWLVMEYCLG 120 SASDLLEVHK 130 KPLQEVEIAA 140 VTHGALQGLA 150 YLHSHNMIHR 160 DVKAGNILLS 170 EPGLVKLGDF 180 GSASIMAPAN 190 SFVGTPYWMA 200 PEVILAMDEG 210 QYDGKVDVWS 220 LGITCIELAE 230 RKPPLFNMNA 240 MSALYHIAQN 250 ESPVLQSGHW 260 SEYFRNFVDS 270 CLQKIPQDRP 280 TSEVLLKHRF 290 VLRERPPTVI 300 MDLIQRTKDA 310 VRELDNLQYR 320 KMKKILFQEA 330 PNGPGAEAPE 340 EEEEAEPYMH 350 RAGTLTSLES 360 SHSVPSMSIS 370 ASSQSSSVNS 380 LADASDNEEE 390 EEEEEEEEEE 400 EEGPEAREMA 410 MMQEGEHTVT 420 SHSSIIHRLP 430 GSDNLYDDPY 440 QPEITPSPLQ 450 PPAAPAPTST 460 TSSARRRAYC 470 RNRDHFATIR 480 TASLVSRQIQ 490 EHEQDSALRE 500 QLSGYKRMRR 510 QHQKQLLALE 520 SRLRGEREEH 530 SARLQRELEA 540 QRAGFGAEAE 550 KLARRHQAIG 560 EKEARAAQAE 570 ERKFQQHILG 580 QQKKELAALL 590 EAQKRTYKLR 600 KEQLKEELQE 610 NPSTPKREKA 620 EWLLRQKEQL 630 QQCQAEEEAG 640 LLRRQRQYFE 650 LQCRQYKRKM 660 LLARHSLDQD 670 LLREDLNKKQ 680 TQKDLECALL 690 LRQHEATREL 700 ELRQLQAVQR 710 TRAELTRLQH 720 QTELGNQLEY 730 NKRREQELRQ 740 KHAAQVRQQP 750 KSLKVRAGQR 760 PPGLPLPIPG 770 ALGPPNTGTP 780 IEQQPCSPGQ 790 EAVLDQRMLG 800 EEEEAVGERR 810 ILGKEGATLE 820 PKQQRILGEE 830 SGAPSPSPQK 840 HGSLVDEEVW 850 GLPEEIEELR 860 VPSLVPQERS 870 IVGQEEAGTW 880 SLWGKEDESL 890 LDEEFELGWV 900 QGPALTPVPE 910 EEEEEEEGAP 920 IGTPRDPGDG 930 CPSPDIPPEP 940 PPTHLRPCPA 950 SQLPGLLSHG 960 LLAGLSFAVG 970 SSSGLLPLLL 980 LLLLPLLAAQ 990 GGGGLQAALL 1000 ALEVGLVGLG 1010 ASYLLLCTAL 1020 HLPSSLFLLL 1030 AQGTALGAVL 1040 GLSWRRGLMG 1050 VPLGLGAAWL 1060 LAWPGLALPL 1070 VAMAAGGRWV 1080 RQQGPRVRRG 1090 ISRLWLRVLL 1100 RLSPMAFRAL 1110 QGCGAVGDRG 1120 LFALYPKTNK 1130 DGFRSRLPVP 1140 GPRRRNPRTT 1150 QHPLALLARV 1160 WVLCKGWNWR 1170 LARASQGLAS 1180 HLPPWAIHTL 1190 ASWGLLRGER 1200 PTRIPRLLPR 1210 SQRQLGPPAS 1220 RQPLPGTLAG 1230 RRSRTRQSRA LPPWR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0030424	axon
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0030659	cytoplasmic vesicle membrane
Cellular Component	GO:0044294	dendritic growth cone
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0043235	receptor complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004709	MAP kinase kinase kinase activity
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding
Molecular Function	GO:0038191	neuropilin binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0048156	tau protein binding
Molecular Function	GO:0050321	tau-protein kinase activity
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0007409	axonogenesis
Biological Process	GO:0150020	basal dendrite arborization
Biological Process	GO:0150019	basal dendrite morphogenesis
Biological Process	GO:0016477	cell migration
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0048041	focal adhesion assembly
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade
Biological Process	GO:0006612	protein targeting to membrane
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:0001558	regulation of cell growth
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0051403	stress-activated MAPK cascade

Reference

PMID: N/A