Search Results

Overview

Uniprot ID	Q9ULC5
Protein Name	Long-chain-fatty-acid--CoA ligase 5
Gene Name	ACSL5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
361	LLNRIYDKVQNEAKT
546	DRKKNIFKLAQGEYI
62	ARKGVSQKNNDLTSC
633	IGKESGLKTFEQVKA
660	GLLTPTLKAKRGELS

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells

Protein Sequence

10 MLFIFNFLFS 20 PLPTPALICI 30 LTFGAAIFLW 40 LITRPQPVLP 50 LLDLNNQSVG 60 IEGGARKGVS 70 QKNNDLTSCC 80 FSDAKTMYEV 90 FQRGLAVSDN 100 GPCLGYRKPN 110 QPYRWLSYKQ 120 VSDRAEYLGS 130 CLLHKGYKSS 140 PDQFVGIFAQ 150 NRPEWIISEL 160 ACYTYSMVAV 170 PLYDTLGPEA 180 IVHIVNKADI 190 AMVICDTPQK 200 ALVLIGNVEK 210 GFTPSLKVII 220 LMDPFDDDLK 230 QRGEKSGIEI 240 LSLYDAENLG 250 KEHFRKPVPP 260 SPEDLSVICF 270 TSGTTGDPKG 280 AMITHQNIVS 290 NAAAFLKCVE 300 HAYEPTPDDV 310 AISYLPLAHM 320 FERIVQAVVY 330 SCGARVGFFQ 340 GDIRLLADDM 350 KTLKPTLFPA 360 VPRLLNRIYD 370 KVQNEAKTPL 380 KKFLLKLAVS 390 SKFKELQKGI 400 IRHDSFWDKL 410 IFAKIQDSLG 420 GRVRVIVTGA 430 APMSTSVMTF 440 FRAAMGCQVY 450 EAYGQTECTG 460 GCTFTLPGDW 470 TSGHVGVPLA 480 CNYVKLEDVA 490 DMNYFTVNNE 500 GEVCIKGTNV 510 FKGYLKDPEK 520 TQEALDSDGW 530 LHTGDIGRWL 540 PNGTLKIIDR 550 KKNIFKLAQG 560 EYIAPEKIEN 570 IYNRSQPVLQ 580 IFVHGESLRS 590 SLVGVVVPDT 600 DVLPSFAAKL 610 GVKGSFEELC 620 QNQVVREAIL 630 EDLQKIGKES 640 GLKTFEQVKA 650 IFLHPEPFSI 660 ENGLLTPTLK 670 AKRGELSKYF 680 RTQIDSLYEH IQD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity
Molecular Function	GO:0090434	oleoyl-CoA ligase activity
Biological Process	GO:0001676	long-chain fatty acid metabolic process
Biological Process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
Biological Process	GO:0010747	positive regulation of long-chain fatty acid import across plasma membrane
Biological Process	GO:2001236	regulation of extrinsic apoptotic signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.