Search Results

Overview

Uniprot IDQ9ULD0
Protein Name2-oxoglutarate dehydrogenase-like, mitochondrial
Gene NameOGDHL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
323 IFCQFDPKLEAADEG

Function

2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (PubMed:23152800, PubMed:31175094)

Protein Sequence

10 MSQLRLLPSR 20 LGVQAARLLA 30 AHDVPVFGWR 40 SRSSGPPATF 50 PSSKGGGGSS 60 YMEEMYFAWL 70 ENPQSVHKSW 80 DSFFREASEE 90 AFSGSAQPRP 100 PSVVHESRSA 110 VSSRTKTSKL 120 VEDHLAVQSL 130 IRAYQIRGHH 140 VAQLDPLGIL 150 DADLDSFVPS 160 DLITTIDKLA 170 FYDLQEADLD 180 KEFQLPTTTF 190 IGGSENTLSL 200 REIIRRLENT 210 YCQHIGLEFM 220 FINDVEQCQW 230 IRQKFETPGV 240 MQFSSEEKRT 250 LLARLVRSMR 260 FEDFLARKWS 270 SEKRFGLEGC 280 EVMIPALKTI 290 IDKSSEMGIE 300 NVILGMPHRG 310 RLNVLANVIR 320 KDLEQIFCQF 330 DPKLEAADEG 340 SGDVKYHLGM 350 YHERINRVTN 360 RNITLSLVAN 370 PSHLEAVDPV 380 VQGKTKAEQF 390 YRGDAQGKKV 400 MSILVHGDAA 410 FAGQGVVYET 420 FHLSDLPSYT 430 TNGTVHVVVN 440 NQIGFTTDPR 450 MARSSPYPTD 460 VARVVNAPIF 470 HVNADDPEAV 480 IYVCSVAAEW 490 RNTFNKDVVV 500 DLVCYRRRGH 510 NEMDEPMFTQ 520 PLMYKQIHRQ 530 VPVLKKYADK 540 LIAEGTVTLQ 550 EFEEEIAKYD 560 RICEEAYGRS 570 KDKKILHIKH 580 WLDSPWPGFF 590 NVDGEPKSMT 600 CPATGIPEDM 610 LTHIGSVASS 620 VPLEDFKIHT 630 GLSRILRGRA 640 DMTKNRTVDW 650 ALAEYMAFGS 660 LLKEGIHVRL 670 SGQDVERGTF 680 SHRHHVLHDQ 690 EVDRRTCVPM 700 NHLWPDQAPY 710 TVCNSSLSEY 720 GVLGFELGYA 730 MASPNALVLW 740 EAQFGDFHNT 750 AQCIIDQFIS 760 TGQAKWVRHN 770 GIVLLLPHGM 780 EGMGPEHSSA 790 RPERFLQMSN 800 DDSDAYPAFT 810 KDFEVSQLYD 820 CNWIVVNCST 830 PANYFHVLRR 840 QILLPFRKPL 850 IIFTPKSLLR 860 HPEAKSSFDQ 870 MVSGTSFQRV 880 IPEDGAAARA 890 PEQVQRLIFC 900 TGKVYYDLVK 910 ERSSQDLEEK 920 VAITRLEQIS 930 PFPFDLIKQE 940 AEKYPGAELA 950 WCQEEHKNMG 960 YYDYISPRFM 970 TILRRARPIW 980 YVGRDPAAAP 990 ATGNRNTHLV 1000 SLKKFLDTAF 1010 NLQAFEGKTF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045252 oxoglutarate dehydrogenase complex
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
Molecular Function GO:0030976 thiamine pyrophosphate binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.