Search Results

Overview

Uniprot IDQ9ULH1
Protein NameArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Gene NameASAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
905 PQKVALRKTDHLSLD

Function

Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879)

Protein Sequence

10 MRSSASRLSS 20 FSSRDSLWNR 30 MPDQISVSEF 40 IAETTEDYNS 50 PTTSSFTTRL 60 HNCRNTVTLL 70 EEALDQDRTA 80 LQKVKKSVKA 90 IYNSGQDHVQ 100 NEENYAQVLD 110 KFGSNFLSRD 120 NPDLGTAFVK 130 FSTLTKELST 140 LLKNLLQGLS 150 HNVIFTLDSL 160 LKGDLKGVKG 170 DLKKPFDKAW 180 KDYETKFTKI 190 EKEKREHAKQ 200 HGMIRTEITG 210 AEIAEEMEKE 220 RRLFQLQMCE 230 YLIKVNEIKT 240 KKGVDLLQNL 250 IKYYHAQCNF 260 FQDGLKTADK 270 LKQYIEKLAA 280 DLYNIKQTQD 290 EEKKQLTALR 300 DLIKSSLQLD 310 QKEDSQSRQG 320 GYSMHQLQGN 330 KEYGSEKKGY 340 LLKKSDGIRK 350 VWQRRKCSVK 360 NGILTISHAT 370 SNRQPAKLNL 380 LTCQVKPNAE 390 DKKSFDLISH 400 NRTYHFQAED 410 EQDYVAWISV 420 LTNSKEEALT 430 MAFRGEQSAG 440 ENSLEDLTKA 450 IIEDVQRLPG 460 NDICCDCGSS 470 EPTWLSTNLG 480 ILTCIECSGI 490 HREMGVHISR 500 IQSLELDKLG 510 TSELLLAKNV 520 GNNSFNDIME 530 ANLPSPSPKP 540 TPSSDMTVRK 550 EYITAKYVDH 560 RFSRKTCSTS 570 SAKLNELLEA 580 IKSRDLLALI 590 QVYAEGVELM 600 EPLLEPGQEL 610 GETALHLAVR 620 TADQTSLHLV 630 DFLVQNCGNL 640 DKQTALGNTV 650 LHYCSMYSKP 660 ECLKLLLRSK 670 PTVDIVNQAG 680 ETALDIAKRL 690 KATQCEDLLS 700 QAKSGKFNPH 710 VHVEYEWNLR 720 QEEIDESDDD 730 LDDKPSPIKK 740 ERSPRPQSFC 750 HSSSISPQDK 760 LALPGFSTPR 770 DKQRLSYGAF 780 TNQIFVSTST 790 DSPTSPTTEA 800 PPLPPRNAGK 810 GPTGPPSTLP 820 LSTQTSSGSS 830 TLSKKRPPPP 840 PPGHKRTLSD 850 PPSPLPHGPP 860 NKGAVPWGND 870 GGPSSSSKTT 880 NKFEGLSQQS 890 STSSAKTALG 900 PRVLPKLPQK 910 VALRKTDHLS 920 LDKATIPPEI 930 FQKSSQLAEL 940 PQKPPPGDLP 950 PKPTELAPKP 960 QIGDLPPKPG 970 ELPPKPQLGD 980 LPPKPQLSDL 990 PPKPQMKDLP 1000 PKPQLGDLLA 1010 KSQTGDVSPK 1020 AQQPSEVTLK 1030 SHPLDLSPNV 1040 QSRDAIQKQA 1050 SEDSNDLTPT 1060 LPETPVPLPR 1070 KINTGKNKVR 1080 RVKTIYDCQA 1090 DNDDELTFIE 1100 GEVIIVTGEE 1110 DQEWWIGHIE 1120 GQPERKGVFP VSFVHILSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0060271 cilium assembly
Biological Process GO:1903527 positive regulation of membrane tubulation
Biological Process GO:0061512 protein localization to cilium

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.