Search Results

Overview

Uniprot IDQ9ULJ3
Protein NameZinc finger and BTB domain-containing protein 21
Gene NameZBTB21
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
161 SRNEAQGKTVSQNQP
218 DSSVVYAKSLEHSGS
264 GVSGQLPKGKALELA
266 SGQLPKGKALELALK
273 KALELALKRPRPPVL

Function

Acts as a transcription repressor

Protein Sequence

10 MEGLLHYINP 20 AHAISLLSAL 30 NEERLKGQLC 40 DVLLIVGDQK 50 FRAHKNVLAA 60 SSEYFQSLFT 70 NKENESQTVF 80 QLDFCEPDAF 90 DNVLNYIYSS 100 SLFVEKSSLA 110 AVQELGYSLG 120 ISFLTNIVSK 130 TPQAPFPTCP 140 NRKKVFVEDD 150 ENSSQKRSVI 160 VCQSRNEAQG 170 KTVSQNQPDV 180 SHTSRPSPSI 190 AVKANTNKPH 200 VPKPIEPLHN 210 LSLTEKSWPK 220 DSSVVYAKSL 230 EHSGSLDDPN 240 RISLVKRNAV 250 LPSKPLQDRE 260 AMDDKPGVSG 270 QLPKGKALEL 280 ALKRPRPPVL 290 SVCSSSETPY 300 LLKETNKGNG 310 QGEDRNLLYY 320 SKLGLVIPSS 330 GSGSGNQSID 340 RSGPLVKSLL 350 RRSLSMDSQV 360 PVYSPSIDLK 370 SSQGSSSVSS 380 DAPGNVLCAL 390 SQKSSLKDCS 400 EKTALDDRPQ 410 VLQPHRLRSF 420 SASQSTDREG 430 ASPVTEVRIK 440 TEPSSPLSDP 450 SDIIRVTVGD 460 AATTAAASSS 470 SVTRDLSLKT 480 EDDQKDMSRL 490 PAKRRFQADR 500 RLPFKKLKVN 510 EHGSPVSEDN 520 FEEGSSPTLL 530 DADFPDSDLN 540 KDEFGELEGT 550 RPNKKFKCKH 560 CLKIFRSTAG 570 LHRHVNMYHN 580 PEKPYACDIC 590 HKRFHTNFKV 600 WTHCQTQHGI 610 VKNPSPASSS 620 HAVLDEKFQR 630 KLIDIVRERE 640 IKKALIIKLR 650 RGKPGFQGQS 660 SSQAQQVIKR 670 NLRSRAKGAY 680 ICTYCGKAYR 690 FLSQFKQHIK 700 MHPGEKPLGV 710 NKVAKPKEHA 720 PLASPVENKE 730 VYQCRLCNAK 740 LSSLLEQGSH 750 ERLCRNAAVC 760 PYCSLRFFSP 770 ELKQEHESKC 780 EYKKLTCLEC 790 MRTFKSSFSI 800 WRHQVEVHNQ 810 NNMAPTENFS 820 LPVLDHNGDV 830 TGSSRPQSQP 840 EPNKVNHIVT 850 TKDDNVFSDS 860 SEQVNFDSED 870 SSCLPEDLSL 880 SKQLKIQVKE 890 EPVEEAEEEA 900 PEASTAPKEA 910 GPSKEASLWP 920 CEKCGKMFTV 930 HKQLERHQEL 940 LCSVKPFICH 950 VCNKAFRTNF 960 RLWSHFQSHM 970 SQASEESAHK 980 ESEVCPVPTN 990 SPSPPPLPPP 1000 PPLPKIQPLE 1010 PDSPTGLSEN 1020 PTPATEKLFV 1030 PQESDTLFYH 1040 APPLSAITFK 1050 RQFMCKLCHR 1060 TFKTAFSLWS HEQTHN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008327 methyl-CpG binding
Molecular Function GO:0031208 POZ domain binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.