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Overview

Uniprot IDQ9ULJ6
Protein NameZinc finger MIZ domain-containing protein 1
Gene NameZMIZ1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
843 DPDGIPSKRFKTMSP

Function

Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322)

Protein Sequence

10 MNSMDRHIQQ 20 TNDRLQCIKQ 30 HLQNPANFHN 40 AATELLDWCG 50 DPRAFQRPFE 60 QSLMGCLTVV 70 SRVAAQQGFD 80 LDLGYRLLAV 90 CAANRDKFTP 100 KSAALLSSWC 110 EELGRLLLLR 120 HQKSRQSDPP 130 GKLPMQPPLS 140 SMSSMKPTLS 150 HSDGSFPYDS 160 VPWQQNTNQP 170 PGSLSVVTTV 180 WGVTNTSQSQ 190 VLGNPMANAN 200 NPMNPGGNPM 210 ASGMTTSNPG 220 LNSPQFAGQQ 230 QQFSAKAGPA 240 QPYIQQSMYG 250 RPNYPGSGGF 260 GASYPGGPNA 270 PAGMGIPPHT 280 RPPADFTQPA 290 AAAAAAAVAA 300 AAATATATAT 310 ATVAALQETQ 320 NKDINQYGPM 330 GPTQAYNSQF 340 MNQPGPRGPA 350 SMGGSMNPAS 360 MAAGMTPSGM 370 SGPPMGMNQP 380 RPPGISPFGT 390 HGQRMPQQTY 400 PGPRPQSLPI 410 QNIKRPYPGE 420 PNYGNQQYGP 430 NSQFPTQPGQ 440 YPAPNPPRPL 450 TSPNYPGQRM 460 PSQPSSGQYP 470 PPTVNMGQYY 480 KPEQFNGQNN 490 TFSGSSYSNY 500 SQGNVNRPPR 510 PVPVANYPHS 520 PVPGNPTPPM 530 TPGSSIPPYL 540 SPSQDVKPPF 550 PPDIKPNMSA 560 LPPPPANHND 570 ELRLTFPVRD 580 GVVLEPFRLE 590 HNLAVSNHVF 600 HLRPTVHQTL 610 MWRSDLELQF 620 KCYHHEDRQM 630 NTNWPASVQV 640 SVNATPLTIE 650 RGDNKTSHKP 660 LHLKHVCQPG 670 RNTIQITVTA 680 CCCSHLFVLQ 690 LVHRPSVRSV 700 LQGLLKKRLL 710 PAEHCITKIK 720 RNFSSVAASS 730 GNTTLNGEDG 740 VEQTAIKVSL 750 KCPITFRRIQ 760 LPARGHDCKH 770 VQCFDLESYL 780 QLNCERGTWR 790 CPVCNKTALL 800 EGLEVDQYMW 810 GILNAIQHSE 820 FEEVTIDPTC 830 SWRPVPIKSD 840 LHIKDDPDGI 850 PSKRFKTMSP 860 SQMIMPNVME 870 MIAALGPGPS 880 PYPLPPPPGG 890 TNSNDYSSQG 900 NNYQGHGNFD 910 FPHGNPGGTS 920 MNDFMHGPPQ 930 LSHPPDMPNN 940 MAALEKPLSH 950 PMQETMPHAG 960 SSDQPHPSIQ 970 QGLHVPHPSS 980 QSGPPLHHSG 990 APPPPPSQPP 1000 RQPPQAAPSS 1010 HPHSDLTFNP 1020 SSALEGQAGA 1030 QGASDMPEPS 1040 LDLLPELTNP 1050 DELLSYLDPP 1060 DLPSNSNDDL LSLFENN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046332 SMAD binding
Molecular Function GO:0061665 SUMO ligase activity
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030521 androgen receptor signaling pathway
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0045582 positive regulation of T cell differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0021852 pyramidal neuron migration to cerebral cortex
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.