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Overview

Uniprot IDQ9ULK4
Protein NameMediator of RNA polymerase II transcription subunit 23
Gene NameMED23
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
120 QLWALTFKLVRKIIG

Function

Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling

Protein Sequence

10 METQLQSIFE 20 EVVKTEVIEE 30 AFPGMFMDTP 40 EDEKTKLISC 50 LGAFRQFWGG 60 LSQESHEQCI 70 QWIVKFIHGQ 80 HSPKRISFLY 90 DCLAMAVETG 100 LLPPRLVCES 110 LINSDTLEWE 120 RTQLWALTFK 130 LVRKIIGGVD 140 YKGVRDLLKV 150 ILEKILTIPN 160 TVSSAVVQQL 170 LAAREVIAYI 180 LERNACLLPA 190 YFAVTEIRKL 200 YPEGKLPHWL 210 LGNLVSDFVD 220 TFRPTARINS 230 ICGRCSLLPV 240 VNNSGAICNS 250 WKLDPATLRF 260 PLKGLLPYDK 270 DLFEPQTALL 280 RYVLEQPYSR 290 DMVCNMLGLN 300 KQHKQRCPVL 310 EDQLVDLVVY 320 AMERSETEEK 330 FDDGGTSQLL 340 WQHLSSQLIF 350 FVLFQFASFP 360 HMVLSLHQKL 370 AGRGLIKGRD 380 HLMWVLLQFI 390 SGSIQKNALA 400 DFLPVMKLFD 410 LLYPEKEYIP 420 VPDINKPQST 430 HAFAMTCIWI 440 HLNRKAQNDN 450 SKLQIPIPHS 460 LRLHHEFLQQ 470 SLRNKSLQMN 480 DYKIALLCNA 490 YSTNSECFTL 500 PMGALVETIY 510 GNGIMRIPLP 520 GTNCMASGSI 530 TPLPMNLLDS 540 LTVHAKMSLI 550 HSIATRVIKL 560 AHAKSSVALA 570 PALVETYSRL 580 LVYMEIESLG 590 IKGFISQLLP 600 TVFKSHAWGI 610 LHTLLEMFSY 620 RMHHIQPHYR 630 VQLLSHLHTL 640 AAVAQTNQNQ 650 LHLCVESTAL 660 RLITALGSSE 670 VQPQFTRFLS 680 DPKTVLSAES 690 EELNRALILT 700 LARATHVTDF 710 FTGSDSIQGT 720 WCKDILQTIM 730 SFTPHNWASH 740 TLSCFPGPLQ 750 AFFKQNNVPQ 760 ESRFNLKKNV 770 EEEYRKWKSM 780 SNENDIITHF 790 SMQGSPPLFL 800 CLLWKMLLET 810 DHINQIGYRV 820 LERIGARALV 830 AHVRTFADFL 840 VYEFSTSAGG 850 QQLNKCIEIL 860 NDMVWKYNIV 870 TLDRLILCLA 880 MRSHEGNEAQ 890 VCYFIIQLLL 900 LKPNDFRNRV 910 SDFVKENSPE 920 HWLQNDWHTK 930 HMNYHKKYPE 940 KLYFEGLAEQ 950 VDPPVQIQSP 960 YLPIYFGNVC 970 LRFLPVFDIV 980 IHRFLELLPV 990 SKSLETLLDH 1000 LGGLYKFHDR 1010 PVTYLYNTLH 1020 YYEMHLRDRA 1030 FLKRKLVHAI 1040 IGSLKDNRPQ 1050 GWCLSDTYLK 1060 CAMNAREENP 1070 WVPDDTYYCR 1080 LIGRLVDTMA 1090 GKSPGPFPNC 1100 DWRFNEFPNP 1110 AAHALHVTCV 1120 ELMALAVSGK 1130 EVGNALLNVV 1140 LKSQPLVPRE 1150 NITAWMNAIG 1160 LIITALPEPY 1170 WIVLHDRIVS 1180 VISSPSLTSE 1190 TEWVGYPFRL 1200 FDFTACHQSY 1210 SEMSCSYTLA 1220 LAHAVWHHSS 1230 IGQLSLIPKF 1240 LTEVLLPIVK 1250 TEFQLLYVYH 1260 LVGPFLQRFQ 1270 QERTRCMIEI 1280 GVAFYDMLLN 1290 VDQCSTHLNY 1300 MDPICDFLYH 1310 MKYMFTGDSV 1320 KEQVEKIICN 1330 LKPALKLRLR 1340 FITHISKMEP 1350 AAVPPQAMNS 1360 GSPAPQSNQV PVSLPVTQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

PMID: N/A