Search Results

Overview

Uniprot IDQ9ULL5
Protein NameProline-rich protein 12
Gene NamePRR12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1068 SPIFCSTKPKKLLKT
1074 TKPKKLLKTSSFHLL
1226 LEPLKPLKIKLSVPK
1228 PLKPLKIKLSVPKAG
1233 KIKLSVPKAGEGLGT
1613 VQKALLQKFTPEIKD
1655 KFLENVNKKDYVRVC
1783 PATSRLPKARPTKVK
27 WSYERSAKASLVYGS

Function

May play a role in the regulation of cohesin complex loading onto chromatin, probably acting in coordination with NIPBL and MAU2

Protein Sequence

10 MDRNYPSAGF 20 GDPLGAGAGW 30 SYERSAKASL 40 VYGSSRTSHP 50 ETDILHRQAY 60 AAPHPLQSYA 70 TNHHPAGLSG 80 LFDTGLHHAG 90 SAGPDASVMN 100 LISALESRGP 110 QPGPSASSLL 120 SQFRSPSWQT 130 AMHTPGPTEL 140 FISGALPGSS 150 TFPSSSALSA 160 YQHPASFGSR 170 PFPVPSSLSL 180 QDPPFSPPAN 190 GLLSPHDVLH 200 LKPSQAPTVP 210 SSLGFERLAG 220 GGVLGPAGLG 230 PAQTPPYRPG 240 PPDPPPPPRH 250 LPTQFNLLAS 260 SSAAAAAAEQ 270 SSPQLYNFSG 280 AAPGPPPPER 290 ALPRQDTVIK 300 HYQRPASAQP 310 PPPPPPAHAL 320 QHYLSCGGSY 330 PSMGHRANLA 340 CSPLGGGEPS 350 PGAGEPSKAG 360 PSGATAGASG 370 RATGPEAAGG 380 GGAGGGGGGY 390 RPIIQSPGYK 400 TGKGGYGAAA 410 GGATRPPPPR 420 STATPKCQSL 430 GGPAAAYATG 440 KASGAGGAGG 450 QAYSPGQPQG 460 LLGPQAYGQG 470 FGGGQAQDLS 480 KAPSYSGGPP 490 QPPSGPPPPG 500 LATCQSYSPD 510 QLQGQLYGVQ 520 GEPYPGPAAH 530 SQGLPTASPS 540 LSYSTGHSPA 550 LSGHGGGWGP 560 SSLGGGGEAS 570 PSHIIRPLQS 580 PPATGRPPGV 590 GSPGAPGKYL 600 SSVLASAPFL 610 APPGAGSYAA 620 GAGGYKGKGD 630 GSELLAGPGG 640 PPAERTEDEE 650 FLIQHLLQAP 660 SPPRTSGADG 670 LVGEDGAADA 680 SKGLGGSGGA 690 GGPPGTPYEL 700 AKEDPQRYHL 710 QSVIRTSASL 720 DEGATAALEL 730 GLGRLKEKKK 740 GPERGGETPE 750 GLATSVVHYG 760 AGAKELGAFL 770 QKSPPPPPPT 780 AQSTQPTPHG 790 LLLEAGGPDL 800 PLVLPPPPPQ 810 LLPSVLSHAP 820 SPSPSASKVG 830 VHLLEPATRD 840 GAPQPPPPPP 850 PPPPPMPLQL 860 EAHLRSHGLE 870 PAAPSPRLRP 880 EESLDPPGAM 890 QELLGALEPL 900 PPAPGDTGVG 910 PPNSEGKDPA 920 GAYRSPSPQG 930 TKAPRFVPLT 940 SICFPDSLLQ 950 DEERSFFPTM 960 EEMFGGGAAD 970 DYGKAGPPED 980 EGDPKAGAGP 990 PPGPPAYDPY 1000 GPYCPGRASG 1010 AGPETPGLGL 1020 DPNKPPELPS 1030 TVNAEPLGLI 1040 QSGPHQAAPP 1050 PPPPPPPPPA 1060 PASEPKGGLT 1070 SPIFCSTKPK 1080 KLLKTSSFHL 1090 LRRRDPPFQT 1100 PKKLYAQEYE 1110 FEADEDKADV 1120 PADIRLNPRR 1130 LPDLVSSCRS 1140 RPALSPLGDI 1150 DFCPPNPGPD 1160 GPRRRGRKPT 1170 KAKRDGPPRP 1180 RGRPRIRPLE 1190 VPTTAGPASA 1200 STPTDGAKKP 1210 RGRGRGRGRK 1220 AEEAGGTRLE 1230 PLKPLKIKLS 1240 VPKAGEGLGT 1250 SSGDAISGTD 1260 HNSLDSSLTR 1270 EKIEAKIKEV 1280 EEKQPEMKSG 1290 FMASFLDFLK 1300 SGKRHPPLYQ 1310 AGLTPPLSPP 1320 KSVPPSVPAR 1330 GLQPQPPATP 1340 AVPHPPPSGA 1350 FGLGGALEAA 1360 ESEGLGLGCP 1370 SPCKRLDEEL 1380 KRNLETLPSF 1390 SSDEEDSVAK 1400 NRDLQESISS 1410 AISALDDPPL 1420 AGPKDTSTPD 1430 GPPLAPAAAV 1440 PGPPPLPGLP 1450 SANSNGTPEP 1460 PLLEEKPPPT 1470 PPPAPTPQPQ 1480 PPPPPPPPQP 1490 ALPSPPPLVA 1500 PTPSSPPPPP 1510 LPPPPPPAMP 1520 SPPPPPPPAA 1530 APLAAPPEEP 1540 AAPSPEDPEL 1550 PDTRPLHLAK 1560 KQETAAVCGE 1570 TDEEAGESGG 1580 EGIFRERDEF 1590 VIRAEDIPSL 1600 KLALQTGREP 1610 PPIWRVQKAL 1620 LQKFTPEIKD 1630 GQRQFCATSN 1640 YLGYFGDAKN 1650 RYQRLYVKFL 1660 ENVNKKDYVR 1670 VCARKPWHRP 1680 PVPVRRSGQA 1690 KNPVSAGGSS 1700 APPPKAPAPP 1710 PKPETPEKTT 1720 SEKPPEQTPE 1730 TAMPEPPAPE 1740 KPSLLRPVEK 1750 EKEKEKVTRG 1760 ERPLRGERAT 1770 SGRQTRPERS 1780 LATGQPATSR 1790 LPKARPTKVK 1800 AEPPPKKRKK 1810 WLKEAGGNAT 1820 AGGGPPGSSS 1830 DSESSPGAPS 1840 EDERAVPGRL 1850 LKTRAMREMY 1860 RSYVEMLVST 1870 ALDPDMIQAL 1880 EDTHDELYLP 1890 PMRKIDGLLN 1900 EHKKKVLKRL 1910 SLSPALQDAL 1920 HTFPQLQVEQ 1930 SGEGSPEEGA 1940 VRLRPAGEPY 1950 NRKTLSKLKR 1960 SVVRAQEFKV 1970 ELEKSGYYTL 1980 YHSLHHYKYH 1990 TFLRCRDQTL 2000 AIEGGAEDLG 2010 QEEVVQQCMR 2020 NQPWLEQLFD 2030 SFSDLLAQAQ AHSRCG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005634 nucleus
Cellular Component GO:0014069 postsynaptic density
Biological Process GO:0008104 intracellular protein localization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.